Analytical Data
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Gene name
SIX4
- Application
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Alternative Names
AREC 3; AREC3; Homeobox protein SIX4; MGC119450; MGC119452; MGC119453; Sine oculis homeobox homolog 4; SIX homeobox 4; Six4; SIX4_HUMAN
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q9UIU6
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Expression Region
2-781 aa
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AA Sequence
SSSSPTGQI ASAADIKQEN GMESASEGQE AHREVAGGAA VGLSPPAPAP FPLEPGDAAT AAARVSGEEG AVAAAAAGAA ADQVQLHSEL LGRHHHAAAA AAQTPLAFSP DHVACVCEAL QQGGNLDRLA RFLWSLPQSD LLRGNESLLK ARALVAFHQG IYPELYSILE SHSFESANHP LLQQLWYKAR YTEAERARGR PLGAVDKYRL RRKFPLPRTI WDGEETVYCF KEKSRNALKE LYKQNRYPSP AEKRHLAKIT GLSLTQVSNW FKNRRQRDRN PSETQSKSES DGNPSTEDES SKGHEDLSPH PLSSSSDGIT NLSLSSHMEP VYMQQIGNAK ISLSSSGVLL NGSLVPASTS PVFLNGNSFI QGPSGVILNG LNVGNTQAVA LNPPKMSSNI VSNGISMTDI LGSTSQDVKE FKVLQSSANS ATTTSYSPSV PVSFPGLIPS TEVKREGIQT VASQDGGSVV TFTTPVQINQ YGIVQIPNSG ANSQFLNGSI GFSPLQLPPV SVAASQGNIS VSSSTSDGST FTSESTTVQQ GKVFLSSLAP SAVVYTVPNT GQTIGSVKQE GLERSLVFSQ LMPVNQNAQV NANLSSENIS GSGLHPLASS LVNVSPTHNF SLSPSTLLNP TELNRDIADS QPMSAPVASK STVTSVSNTN YATLQNCSLI TGQDLLSVPM TQAALGEIVP TAEDQVGHPS PAVHQDFVQE HRLVLQSVAN MKENFLSNSE SKATSSLMML DSKSKYVLDG MVDTVCEDLE TDKKELAKLQ TVQLDEDMQD L
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Molecular Weight
82.9 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
SIX4, a member of the SIX (SINE OGlial) family of transcription factors, plays a crucial role in various developmental processes, particularly in the formation of the eye and other sensory organs. Research on SIX4 has gained momentum due to its involvement in key signaling pathways, such as those mediated by Wnt and fibroblast growth factors (FGFs), which are essential for cellular differentiation and organogenesis. The study of SIX4 has significant implications in understanding congenital disorders, as mutations in SIX4 have been associated with developmental abnormalities and diseases. Moreover, the protein's interaction with other transcription factors and its regulatory mechanisms offer insights into gene expression and cellular response to external stimuli. The recombinant production of SIX4 allows researchers to conduct detailed functional assays, structural analyses, and explore its potential therapeutic applications. By elucidating the molecular mechanisms underlying SIX4's role in development and its implications in pathology, scientists aim to uncover novel strategies for intervention in genetic disorders related to SIX4 dysregulation. This growing body of research underscores the significance of SIX4 not only in fundamental biology but also in translational medicine, making it a valuable target for further investigation in developmental biology and therapeutic development.
