Analytical Data
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基因名
Zc3h12a
- Application
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别名
Zc3h12a；MCPIP；MCPIP1；Endoribonuclease ZC3H12A
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q5D1E8
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表达区间
1-599aa
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氨基酸序列
MSGPCGEKPVLEASPTMSLWEFEDSHSRQGTPRPGQELAAEEASALELQMKVDFFRKLGYSSTEIHSVLQKLGVQADTNTVLGELVKHGTATERERQTSPDPCPQLPLVPRGGGTPKAPNLEPPLPEEEKEGSDLRPVVIDGSNVAMSHGNKEVFSCRGILLAVNWFLERGHTDITVFVPSWRKEQPRPDVPITDQHILRELEKKKILVFTPSRRVGGKRVVCYDDRFIVKLAYESDGIVVSNDTYRDLQGERQEWKRFIEERLLMYSFVNDKFMPPDDPLGRHGPSLDNFLRKKPLTLEHRKQPCPYGRKCTYGIKCRFFHPERPSCPQRSVADELRANALLSPPRAPSKDKNGRRPSPSSQSSSLLTESEQCSLDGKKLGAQASPGSRQEGLTQTYAPSGRSLAPSGGSGSSFGPTDWLPQTLDSLPYVSQDCLDSGIGSLESQMSELWGVRGGGPGEPGPPRAPYTGYSPYGSELPATAAFSAFGRAMGAGHFSVPADYPPAPPAFPPREYWSEPYPLPPPTSVLQEPPVQSPGAGRSPWGRAGSLAKEQASVYTKLCGVFPPHLVEAVMGRFPQLLDPQQLAAEILSYKSQHPSE
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分子量
69.8 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
Zc3h12a, a member of the zinc finger protein family, has garnered increasing attention in recent years due to its pivotal role in various biological processes, particularly in immunity and inflammation. Initial studies revealed that Zc3h12a functions as a post-transcriptional regulator of gene expression, influencing the stability and decay of mRNA targets. This regulation is crucial during immune responses, as Zc3h12a modulates the production of pro-inflammatory cytokines, thereby impacting the severity and outcomes of autoimmune diseases and infections. Furthermore, Zc3h12a has been implicated in hematopoiesis and the differentiation of immune cells, suggesting its importance in both innate and adaptive immunological functions. Given its central role in regulating inflammatory responses, investigating Zc3h12a as a therapeutic target holds significant promise for developing novel interventions in diseases characterized by dysregulated inflammation. Recent advances in recombinant protein technology have facilitated the expression and purification of Zc3h12a, enabling in-depth studies of its structure and function. Understanding the molecular mechanisms underlying Zc3h12a's activity could lead to the identification of new biomarkers for disease progression and potential therapeutic strategies to modulate immune responses effectively. Overall, the continued research into Zc3h12a is essential for unraveling its complex role in health and disease, underscoring its potential as a significant player in the field of immunology and beyond.
