Analytical Data
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Gene name
Zc3h12a
- Application
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Alternative Names
Zc3h12a；MCPIP；MCPIP1；Endoribonuclease ZC3H12A
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q5D1E8
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Expression Region
1-599aa
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AA Sequence
MSGPCGEKPVLEASPTMSLWEFEDSHSRQGTPRPGQELAAEEASALELQMKVDFFRKLGYSSTEIHSVLQKLGVQADTNTVLGELVKHGTATERERQTSPDPCPQLPLVPRGGGTPKAPNLEPPLPEEEKEGSDLRPVVIDGSNVAMSHGNKEVFSCRGILLAVNWFLERGHTDITVFVPSWRKEQPRPDVPITDQHILRELEKKKILVFTPSRRVGGKRVVCYDDRFIVKLAYESDGIVVSNDTYRDLQGERQEWKRFIEERLLMYSFVNDKFMPPDDPLGRHGPSLDNFLRKKPLTLEHRKQPCPYGRKCTYGIKCRFFHPERPSCPQRSVADELRANALLSPPRAPSKDKNGRRPSPSSQSSSLLTESEQCSLDGKKLGAQASPGSRQEGLTQTYAPSGRSLAPSGGSGSSFGPTDWLPQTLDSLPYVSQDCLDSGIGSLESQMSELWGVRGGGPGEPGPPRAPYTGYSPYGSELPATAAFSAFGRAMGAGHFSVPADYPPAPPAFPPREYWSEPYPLPPPTSVLQEPPVQSPGAGRSPWGRAGSLAKEQASVYTKLCGVFPPHLVEAVMGRFPQLLDPQQLAAEILSYKSQHPSE
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Molecular Weight
69.8 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
Zc3h12a, a member of the zinc finger protein family, has garnered increasing attention in recent years due to its pivotal role in various biological processes, particularly in immunity and inflammation. Initial studies revealed that Zc3h12a functions as a post-transcriptional regulator of gene expression, influencing the stability and decay of mRNA targets. This regulation is crucial during immune responses, as Zc3h12a modulates the production of pro-inflammatory cytokines, thereby impacting the severity and outcomes of autoimmune diseases and infections. Furthermore, Zc3h12a has been implicated in hematopoiesis and the differentiation of immune cells, suggesting its importance in both innate and adaptive immunological functions. Given its central role in regulating inflammatory responses, investigating Zc3h12a as a therapeutic target holds significant promise for developing novel interventions in diseases characterized by dysregulated inflammation. Recent advances in recombinant protein technology have facilitated the expression and purification of Zc3h12a, enabling in-depth studies of its structure and function. Understanding the molecular mechanisms underlying Zc3h12a's activity could lead to the identification of new biomarkers for disease progression and potential therapeutic strategies to modulate immune responses effectively. Overall, the continued research into Zc3h12a is essential for unraveling its complex role in health and disease, underscoring its potential as a significant player in the field of immunology and beyond.
