Analytical Data
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Gene name
CRELD1
- Application
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Alternative Names
CRELD1；CIRRIN；Protein disulfide isomerase CRELD1
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q96HD1-1
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Expression Region
1-362aa
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AA Sequence
MAPWPPKGLV PAMLWGLSLF LNLPGPIWLQ PSPPPQSSPP PQPHPCHTCR GLVDSFNKGL ERTIRDNFGG GNTAWEEENL SKYKDSETRL VEVLEGVCSK SDFECHRLLE LSEELVESWW FHKQQEAPDL FQWLCSDSLK LCCPAGTFGP SCLPCPGGTE RPCGGYGQCE GEGTRGGSGH CDCQAGYGGE ACGQCGLGYF EAERNASHLV CSACFGPCAR CSGPEESNCL QCKKGWALHH LKCVDIDECG TEGANCGADQ FCVNTEGSYE CRDCAKACLG CMGAGPGRCK KCSPGYQQVG SKCLDVDECE TEVCPGENKQ CENTEGGYRC ICAEGYKQME GICVKEQIPE SAGFFSEMTE DE
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Molecular Weight
37 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
CRELD1, or cysteine-rich with EGF-like domains 1, is a novel protein that has gained attention in the field of developmental biology and congenital heart disease research due to its role in cardiac development and cellular signaling pathways. Disruptions in the CRELD1 gene have been linked to a variety of congenital heart defects, particularly atrioventricular septal defects and other septal malformations, highlighting its importance in proper embryonic heart morphogenesis. Research has shown that CRELD1 is involved in the regulation of cell adhesion and signaling during the critical stages of cardiogenesis, making it a potential target for therapeutic interventions. Recombinant CRELD1 protein production allows for the detailed study of its structural and functional properties, elucidating its mechanisms of action at the molecular level. Investigating the protein-protein interactions and signaling pathways associated with CRELD1 can provide insights into the etiology of heart defects and aid in the development of strategies for prevention and treatment, emphasizing the necessity of understanding this protein in both basic and translational research contexts. Thus, the study of CRELD1 and its recombinant protein form stands as a pivotal component in uncovering the complexities of heart development and disease.
