Analytical Data
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Gene name
CD209
- Application
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Alternative Names
CD209；CLEC4L；CD209 antigen
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q9NNX6
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Expression Region
1-404aa
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AA Sequence
MSDSKEPRLQQLGLLEEEQLRGLGFRQTRGYKSLAGCLGHGPLVLQLLSF TLLAGLLVQVSKVPSSISQEQSRQDAIYQNLTQLKAAVGELSEKSKLQEI YQELTQLKAAVGELPEKSKLQEIYQELTRLKAAVGELPEKSKLQEIYQEL TWLKAAVGELPEKSKMQEIYQELTRLKAAVGELPEKSKQQEIYQELTRLK AAVGELPEKSKQQEIYQELTRLKAAVGELPEKSKQQEIYQELTQLKAAVE RLCHPCPWEWTFFQGNCYFMSNSQRNWHDSITACKEVGAQLVVIKSAEEQ NFLQLQSSRSNRFTWMGLSDLNQEGTWQWVDGSPLLPSFKQYWNRGEPNN VGEEDCAEFSGNGWNDDKCNLAKFWICKKSAASCSRDEEQFLSPAPATPN PPPA
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Molecular Weight
72 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
CD209, also known as dendritic cell-specific intercellular adhesion molecule-3-grabbing non-integrin (DC-SIGN), is a C-type lectin receptor predominantly expressed on dendritic cells and macrophages. It plays a crucial role in the immune response by recognizing and binding to various pathogens, including viruses, bacteria, and fungi, thereby facilitating their uptake and presentation to T cells. The therapeutic potential of CD209 has been a focus of research due to its involvement in pathogen recognition and activation of immune responses. Recombinant CD209 protein has been developed to study its structure-function relationships and interaction with ligands, which is essential for understanding its role in immune modulation and pathogen evasion strategies. Furthermore, CD209 has emerged as a promising target for vaccine development and immunotherapy, as manipulating its expression or activity could enhance immune responses against infectious diseases and cancer. Recent studies have highlighted the significance of CD209 in promoting adaptive immunity and its potential use as a biomarker for disease prognosis. The ongoing exploration of recombinant CD209 protein aims to unveil new therapeutic opportunities and improve our understanding of host-pathogen interactions, contributing to better strategies for combating infectious diseases and improving vaccine efficacy.
