Analytical Data
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Gene name
SETMAR
- Application
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Alternative Names
Histone lysine N methyltransferase; Histone lysine N methyltransferase SETMAR; Hsmar 1; Hsmar1; Mariner transposase Hsmar1; Metnase; SET domain and mariner transposase fusion; SET domain and mariner transposase fusion gene; SET domain and mariner transposase fusion gene containing protein; SET domain and mariner transposase fusion gene-containing protein; Setmar; SETMR_HUMAN
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q53H47
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Expression Region
1-671 aa
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AA Sequence
MAEFKEKPEA PTEQLDVACG QENLPVGAWP PGAAPAPFQY TPDHVVGPGA DIDPTQITFP GCICVKTPCL PGTCSCLRHG ENYDDNSCLR DIGSGGKYAE PVFECNVLCR CSDHCRNRVV QKGLQFHFQV FKTHKKGWGL RTLEFIPKGR FVCEYAGEVL GFSEVQRRIH LQTKSDSNYI IAIREHVYNG QVMETFVDPT YIGNIGRFLN HSCEPNLLMI PVRIDSMVPK LALFAAKDIV PEEELSYDYS GRYLNLTVSE DKERLDHGKL RKPCYCGAKS CTAFLPFDSS LYCPVEKSNI SCGNEKEPSM CGSAPSVFPS CKRLTLETMK MMLDKKQIRA IFLFEFKMGR KAAETTRNIN NAFGPGTANE RTVQWWFKKF CKGDESLEDE ERSGRPSEVD NDQLRAIIEA DPLTTTREVA EELNVNHSTV VRHLKQIGKV KKLDKWVPHE LTENQKNRRF EVSSSLILRN HNEPFLDRIV TCDEKWILYD NRRRSAQWLD QEEAPKHFPK PILHPKKVMV TIWWSAAGLI HYSFLNPGET ITSEKYAQEI DEMNQKLQRL QLALVNRKGP ILLHDNARPH VAQPTLQKLN ELGYEVLPHP PYSPDLLPTN YHVFKHLNNF LQGKRFHNQQ DAENAFQEFV ESQSTDFYAT GINQLISRWQ KCVDCNGSYF D
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Molecular Weight
78.0 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
SETMAR is a unique fusion protein that combines the SET domain of the SET family of proteins with the MAR (Matrix Attachment Region) DNA-binding domain. This protein plays a significant role in genomic stability and regulation of gene expression. The SET domain is known for its methyltransferase activity, contributing to the modification of histones and influencing chromatin structure. SETMAR is particularly interesting because it is believed to be involved in the repair of DNA double-strand breaks, with implications for cancer biology and therapeutic interventions. Its MAR domain facilitates the binding of the protein to the nuclear matrix, thereby playing a crucial role in organizing chromatin architecture. Research into SETMAR has expanded in recent years, focusing on its evolutionary origins, as it originated from a retrotransposon, and its functional contributions to cellular processes. Studying SETMAR not only enhances our understanding of DNA repair mechanisms but also offers insights into the complexities of genome organization and the interplay between genetic elements in eukaryotic cells. These insights could open new avenues for targeted therapies in diseases characterized by genomic instability, such as cancer.
