Analytical Data
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Gene name
NRXN3
- Application
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Alternative Names
NRXN3；KIAA0743；Neurexin-3-beta
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q9HDB5-2
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Expression Region
1-357aa
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AA Sequence
MHLRIHARRS PPRRPAWTLG IWFLFWGCIV SSVWSSSNVA SSSSTSSSPG SHSQHEHHFH GSKHHSVPIS IYRSPVSLRG GHAGATYIFG KSGGLILYTW PANDRPSTRS DRLAVGFSTT VKDGILVRID SAPGLGDFLQ LHIEQGKIGV VFNIGTVDIS IKEERTPVND GKYHVVRFTR NGGNATLQVD NWPVNEHYPT GRQLTIFNTQ AQIAIGGKDK GRLFQGQLSG LYYDGLKVLN MAAENNPNIK INGSVRLVGE VPSILGTTQT TSMPPEMSTT VMETTTTMAT TTTRKNRSTA SIQPTSDDLV SSAECSSDDE DFVECEPSTG RSANPTEPGI RRVPGASEVI RESSSTT
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Molecular Weight
36 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
NRXN3, or Neurexin 3, is a member of the neurexin family, which plays a crucial role in synapse formation and function in the nervous system. This protein is implicated in various neurodevelopmental disorders, including autism spectrum disorders (ASD) and schizophrenia, making it a significant target for biomedical research. The gene encoding NRXN3 has been linked to genetic variations that contribute to these conditions, highlighting its potential role in the pathophysiology of neuropsychiatric disorders. Researchers are particularly interested in the structure and function of NRXN3, as understanding its molecular interactions could provide insights into synaptic dysfunction found in these diseases. Recombinant NRXN3 proteins are essential for studying these interactions and exploring their effects in model systems. By producing and characterizing NRXN3 as a recombinant protein, scientists can investigate its binding affinity with other synaptic proteins, elucidate its role in synaptic signaling, and evaluate how mutations or variations in this protein affect neural function. This research not only enhances our foundational knowledge of synaptic biology but also paves the way for potential therapeutic strategies aimed at targeting NRXN3-related pathways in autism and other neurodevelopmental disorders. Thus, the study of NRXN3 recombinant proteins represents a vital intersection of molecular neuroscience and clinical research, with the potential to advance our understanding of complex neurodevelopmental conditions.
