Analytical Data
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基因名
CDH5
- Application
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别名
CDH5；Cadherin-5
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
P33151
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表达区间
48-599aa
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氨基酸序列
DWIWNQMHIDEEKNTSLPHHVGKIKSSVSRKNAKYLLKGEYVGKVFRVDAETGDVFAIERLDRENISEYHLTAVIVDKDTGENLETPSSFTIKVHDVNDNWPVFTHRLFNASVPESSAVGTSVISVTAVDADDPTVGDHASVMYQILKGKEYFAIDNSGRIITITKSLDREKQARYEIVVEARDAQGLRGDSGTATVLVTLQDINDNFPFFTQTKYTFVVPEDTRVGTSVGSLFVEDPDEPQNRMTKYSILRGDYQDAFTIETNPAHNEGIIKPMKPLDYEYIQQYSFIVEATDPTIDLRYMSPPAGNRAQVIINITDVDEPPIFQQPFYHFQLKENQKKPLIGTVLAMDPDAARHSIGYSIRRTSDKGQFFRVTKKGDIYNEKELDREVYPWYNLTVEAKELDSTGTPTGKESIVQVHIEVLDENDNAPEFAKPYQPKVCENAVHGQLVLQISAIDKDITPRNVKFKFILNTENNFTLTDNHDNTANITVKYGQFDREHTKVHFLPVVISDNGMPSRTGTSTLTVAVCKCNEQGEFTFCEDMAAQVGVSIQ
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分子量
66.1kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
CDH5, also known as vascular endothelial cadherin (VE-cadherin), is a key protein involved in the regulation of endothelial cell adhesion and integrity, playing a critical role in maintaining vascular stability and homeostasis. Its significance extends to various physiological and pathological processes, including angiogenesis, inflammation, and tumor metastasis. The research surrounding CDH5 recombinant proteins has gained momentum due to their potential applications in therapeutic strategies targeting vascular-related diseases and disorders. By producing CDH5 in a recombinant form, scientists are able to study its structural and functional properties in greater detail, elucidate its interactions with other cellular components, and assess its role in disease mechanisms. Moreover, CDH5 recombinant proteins serve as valuable tools for the development of diagnostics and interventions in conditions such as cancer, where perturbation of endothelial function contributes to tumor progression. Understanding CDH5's function through recombinant technologies not only enhances our knowledge of endothelial biology but also paves the way for innovative approaches in regenerative medicine and targeted therapies aimed at restoring vascular integrity in various pathological contexts.
