Analytical Data
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Gene name
CDH5
- Application
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Alternative Names
CDH5；Cadherin-5
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
P33151
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Expression Region
48-599aa
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AA Sequence
DWIWNQMHIDEEKNTSLPHHVGKIKSSVSRKNAKYLLKGEYVGKVFRVDAETGDVFAIERLDRENISEYHLTAVIVDKDTGENLETPSSFTIKVHDVNDNWPVFTHRLFNASVPESSAVGTSVISVTAVDADDPTVGDHASVMYQILKGKEYFAIDNSGRIITITKSLDREKQARYEIVVEARDAQGLRGDSGTATVLVTLQDINDNFPFFTQTKYTFVVPEDTRVGTSVGSLFVEDPDEPQNRMTKYSILRGDYQDAFTIETNPAHNEGIIKPMKPLDYEYIQQYSFIVEATDPTIDLRYMSPPAGNRAQVIINITDVDEPPIFQQPFYHFQLKENQKKPLIGTVLAMDPDAARHSIGYSIRRTSDKGQFFRVTKKGDIYNEKELDREVYPWYNLTVEAKELDSTGTPTGKESIVQVHIEVLDENDNAPEFAKPYQPKVCENAVHGQLVLQISAIDKDITPRNVKFKFILNTENNFTLTDNHDNTANITVKYGQFDREHTKVHFLPVVISDNGMPSRTGTSTLTVAVCKCNEQGEFTFCEDMAAQVGVSIQ
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Molecular Weight
66.1kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
CDH5, also known as vascular endothelial cadherin (VE-cadherin), is a key protein involved in the regulation of endothelial cell adhesion and integrity, playing a critical role in maintaining vascular stability and homeostasis. Its significance extends to various physiological and pathological processes, including angiogenesis, inflammation, and tumor metastasis. The research surrounding CDH5 recombinant proteins has gained momentum due to their potential applications in therapeutic strategies targeting vascular-related diseases and disorders. By producing CDH5 in a recombinant form, scientists are able to study its structural and functional properties in greater detail, elucidate its interactions with other cellular components, and assess its role in disease mechanisms. Moreover, CDH5 recombinant proteins serve as valuable tools for the development of diagnostics and interventions in conditions such as cancer, where perturbation of endothelial function contributes to tumor progression. Understanding CDH5's function through recombinant technologies not only enhances our knowledge of endothelial biology but also paves the way for innovative approaches in regenerative medicine and targeted therapies aimed at restoring vascular integrity in various pathological contexts.
