Analytical Data
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基因名
SEPT4
- Application
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别名
Apoptosis-related protein in the TGF-beta signaling pathway; ARTS; Bradeion; Bradeion beta; Brain protein H5; CE5B3; CE5B3 beta; Cell division control-related protein 2; Cerebral protein 7; H5; hCDCREL-2; hucep-7; MART; Peanut-like protein 2; PNUTL2; SEP 4; SEP4; Sept4; SEPT4_HUMAN; Septin M; Septin-4
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
O43236
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表达区间
1-478 aa
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氨基酸序列
MDRSLGWQGN SVPEDRTEAG IKRFLEDTTD DGELSKFVKD FSGNASCHPP EAKTWASRPQ VPEPRPQAPD LYDDDLEFRP PSRPQSSDNQ QYFCAPAPLS PSARPRSPWG KLDPYDSSED DKEYVGFATL PNQVHRKSVK KGFDFTLMVA GESGLGKSTL VNSLFLTDLY RDRKLLGAEE RIMQTVEITK HAVDIEEKGV RLRLTIVDTP GFGDAVNNTE CWKPVAEYID QQFEQYFRDE SGLNRKNIQD NRVHCCLYFI SPFGHGLRPL DVEFMKALHQ RVNIVPILAK ADTLTPPEVD HKKRKIREEI EHFGIKIYQF PDCDSDEDED FKLQDQALKE SIPFAVIGSN TVVEARGRRV RGRLYPWGIV EVENPGHCDF VKLRTMLVRT HMQDLKDVTR ETHYENYRAQ CIQSMTRLVV KERNRNKLTR ESGTDFPIPA VPPGTDPETE KLIREKDEEL RRMQEMLHKI QKQMKENY
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分子量
55.0 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
SEPT4, or Septin 4, is a member of the septin family of GTP-binding proteins that play crucial roles in various cellular processes, including cytokinesis, cell division, and the maintenance of cell shape. As one of the complex components of the cytoskeleton, SEPT4 has garnered considerable interest in the context of cancer biology and neurodegenerative diseases. The study of SEPT4 is particularly relevant because aberrations in septin function have been implicated in tumor progression and metastasis, suggesting that SEPT4 may serve as a potential biomarker for certain cancers. Additionally, research has indicated that SEPT4 has a role in neural development and synaptic function, which aligns with its potential involvement in neurodegenerative disorders. The reorganization of septins, including SEPT4, in the context of cellular stress, inflammation, and apoptosis underscores its importance in maintaining cellular integrity. Understanding the structure and function of SEPT4, as well as its interactions with other proteins, can provide insights into its regulatory mechanisms and its contributions to disease pathology. Ongoing research is focused on unraveling the molecular pathways associated with SEPT4, aiming to identify novel therapeutic targets for cancer and neurodegenerative diseases.
