Analytical Data
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基因名
SENP3
- Application
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别名
SENP3; SENP3_HUMAN; Sentrin / SUMO specific protease 3; Sentrin specific protease 3; Sentrin-specific protease 3; Sentrin/SUMO-specific protease SENP3; SMT3IP1; SSP3; SUMO 1 specific protease 3; SUMO-1-specific protease 3; SUMO1 specific protease 3 ; SUMO1/sentrin/SMT3 specific peptidase 3; SUSP3
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q9H4L4
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表达区间
1-574 aa
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氨基酸序列
MKETIQGTGS WGPEPPGPGI PPAYSSPRRE RLRWPPPPKP RLKSGGGFGP DPGSGTTVPA RRLPVPRPSF DASASEEEEE EEEEEDEDEE EEVAAWRLPP RWSQLGTSQR PRPSRPTHRK TCSQRRRRAM RAFRMLLYSK STSLTFHWKL WGRHRGRRRG LAHPKNHLSP QQGGATPQVP SPCCRFDSPR GPPPPRLGLL GALMAEDGVR GSPPVPSGPP MEEDGLRWTP KSPLDPDSGL LSCTLPNGFG GQSGPEGERS LAPPDASILI SNVCSIGDHV AQELFQGSDL GMAEEAERPG EKAGQHSPLR EEHVTCVQSI LDEFLQTYGS LIPLSTDEVV EKLEDIFQQE FSTPSRKGLV LQLIQSYQRM PGNAMVRGFR VAYKRHVLTM DDLGTLYGQN WLNDQVMNMY GDLVMDTVPE KVHFFNSFFY DKLRTKGYDG VKRWTKNVDI FNKELLLIPI HLEVHWSLIS VDVRRRTITY FDSQRTLNRR CPKHIAKYLQ AEAVKKDRLD FHQGWKGYFK MNVARQNNDS DCGAFVLQYC KHLALSQPFS FTQQDMPKLR RQIYKELCHC KLTV
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分子量
65.0 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
SENP3, or Sentrin/SUMO-specific protease 3, is a deSUMOylating enzyme belonging to the SENP family, which plays a critical role in the regulation of SUMOylation, a post-translational modification that influences various cellular processes, including protein stability, localization, and activity. The dysregulation of SUMOylation and SENP enzymes is implicated in numerous diseases, particularly cancer, where alterations in these pathways can affect cell proliferation and survival. SENP3 has garnered attention due to its potential as a therapeutic target, as it is known to influence the activity of several key tumor suppressors and oncogenes, thus modulating tumorigenesis. Research on recombinant SENP3 protein involves its expression and purification, enabling detailed studies on its enzymatic activity and interaction with SUMO-modified substrates. Investigating the mechanisms by which SENP3 regulates cellular pathways can provide insights into its role in disease development and progression, paving the way for novel therapeutic strategies aimed at restoring normal SUMOylation dynamics in pathological conditions. This research highlights the significance of SENP3 in the context of cellular homeostasis and disease, emphasizing the need for continued exploration of its functional properties and potential clinical applications.
