Analytical Data
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Gene name
CLDN17
- Application
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Alternative Names
CLDN17; UNQ758/PRO1489; Claudin-17
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Species
Human
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Source
E. coli
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Tag
GST-tag at N-terminal
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
P56750
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Expression Region
1-224aa
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AA Sequence
MAFYPLQIAGLVLGFLGMVGTLATTLLPQWRVSAFVGSNIIVFERLWEGLWMNCIRQARVRLQCKFYSSLLALPPALETARALMCVAVALSLIALLIGICGMKQVQCTGSNERAKAYLLGTSGVLFILTGIFVLIPVSWTANIIIRDFYNPAIHIGQKRELGAALFLGWASAAVLFIGGGLLCGFCCCNRKKQGYRYPVPGYRVPHTDKRRNTTMLSKTSTSYV
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Molecular Weight
51 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
CLDN17, or Claudin-17, is a member of the claudin family of proteins, which are integral components of tight junctions in epithelial tissues. These proteins play a crucial role in maintaining the integrity of cellular barriers and regulating paracellular permeability. Recent studies have identified CLDN17 as a key player in various physiological and pathological processes, particularly in the context of kidney function and gastrointestinal health. Notably, CLDN17 is prominently expressed in the renal proximal tubules and has been implicated in processes such as ion transport, water reabsorption, and the maintenance of homeostasis. Dysregulation of CLDN17 expression has been associated with several conditions, including renal diseases and cancers, where it may contribute to altered cell proliferation and invasion. Given its significant biological roles, research into the recombinant production of CLDN17 protein has gained attention. The ability to produce this protein in a recombinant form can facilitate detailed studies of its structural properties, interactions with other cellular components, and functional assays to elucidate its role in tight junction dynamics. Furthermore, understanding CLDN17's mechanisms of action may provide insights for potential therapeutic targets in diseases where tight junction integrity is compromised. Thus, the study of recombinant CLDN17 not only enhances our comprehension of epithelial physiology but also opens avenues for innovative therapeutic strategies targeting claudin-related pathologies.
