Analytical Data
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基因名
LILRB3
- Application
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别名
LILRB3；ILT5；LIR3；Leukocyte immunoglobulin-like receptor subfamily B member 3
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
O75022
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表达区间
1-443aa
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氨基酸序列
MTPALTALLC LGLSLGPRTR VQAGPFPKPT LWAEPGSVIS WGSPVTIWCQ GSQEAQEYRL HKEGSPEPL DRNNPLEPKN KARFSIPSMT EHHAGRYRCH YYSSAGWSEP SDPLEMVMTG AYSKPTLSA LPSPVVASGG NMTLRCGSQK GYHHFVLMKE GEHQLPRTLD SQQLHSRGFQ ALFPVGPVT PSHRWRFTCY YYYTNTPWVW SHPSDPLEIL PSGVSRKPSL LTLQGPVLAP GQSLTLQCG SDVGYNRFVL YKEGERDFLQ RPGQQPQAGL SQANFTLGPV SPSNGGQYRC YGAHNLSSE WSAPSDPLNI LMAGQIYDTV SLSAQPGPTV ASGENVTLLC QSWWQFDTFL LTKEGAAHP PLRLRSMYGA HKYQAEFPMS PVTSAHAGTY RCYGSYSSNP HLLSHPSEPL ELVVSGHSG GSSLPPTGPP STPGLGRYLE
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分子量
48 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
LILRB3, or leukocyte immunoglobulin-like receptor B3, is a member of the immunoglobulin superfamily that plays a crucial role in the immune system, particularly in the regulation of immune responses. It is predominantly expressed on myeloid and lymphoid cells, where it modulates signaling pathways that affect cell activation, differentiation, and cytokine production. Research has increasingly demonstrated that LILRB3 functions as an inhibitory receptor, negatively regulating immune responses to prevent excessive inflammation and maintaining tissue homeostasis. Due to its role in immune regulation, LILRB3 has garnered interest in the context of various diseases, including cancer, autoimmune disorders, and infectious diseases. Understanding the molecular mechanisms underlying LILRB3 function and its interactions with ligands could provide insights into therapeutic strategies. Moreover, the development of LILRB3 recombinant proteins has become essential for investigating its structure-function relationships and potential as a target for immunotherapy. By producing these recombinant proteins, researchers aim to explore their potential in modulating immune responses, which could lead to novel approaches in enhancing or inhibiting immune activity in different clinical scenarios. Overall, the study of LILRB3 and its recombinant forms represents a promising area of research with significant implications for immunology and therapeutic interventions.
