Analytical Data
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基因名
SENP1
- Application
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别名
Sentrin/SUMO-specific protease SENP1
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q9P0U3
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表达区间
1-644 aa
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氨基酸序列
MDDIADRMRMDAGEVTLVNHNSVFKTHLLPQTGFPEDQLSLSDQQILSSRQGHLDRSFTCSTRSAAYNPSYYSDNPSSDSFLGSGDLRTFGQSANGQWRNSTPSSSSSLQKSRNSRSLYLETRKTSSGLSNSFAGKSNHHCHVSAYEKSFPIKPVPSPSWSGSCRRSLLSPKKTQRRHVSTAEETVQEEEREIYRQLLQMVTGKQFTIAKPTTHFPLHLSRCLSSSKNTLKDSLFKNGNSCASQIIGSDTSSSGSASILTNQEQLSHSVYSLSSYTPDVAFGSKDSGTLHHPHHHHSVPHQPDNLAASNTQSEGSDSVILLKVKDSQTPTPSSTFFQAELWIKELTSVYDSRARERLRQIEEQKALALQLQNQRLQEREHSVHDSVELHLRVPLEKEIPVTVVQETQKKGHKLTDSEDEFPEITEEMEKEIKNVFRNGNQDEVLSEAFRLTITRKDIQTLNHLNWLNDEIINFYMNMLMERSKEKGLPSVHAFNTFFFTKLKTAGYQAVKRWTKKVDVFSVDILLVPIHLGVHWCLAVVDFRKKNITYYDSMGGINNEACRILLQYLKQESIDKKRKEFDTNGWQLFSKKSQEIPQQMNGSDCGMFACKYADCITKDRPINFTQQHMPYFRKRMVWEILHRKLL
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分子量
80.4 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
SENP1 (Sentrin/SUMO-specific protease 1) is a crucial enzyme involved in the post-translational modification process known as SUMOylation, which regulates various cellular functions, including gene expression, signal transduction, and response to stress. Dysregulation of SENP1 has been implicated in several diseases, including cancer, neurological disorders, and cardiovascular diseases, making it a target of interest for therapeutic interventions. Researchers have been focusing on the production and characterization of recombinant SENP1 to better understand its biological functions and mechanisms of action. The recombinant protein can be utilized in various biochemical assays to study its activity, substrate specificity, and interaction with other cellular proteins. Additionally, SENP1's role in regulating cellular dynamics through deSUMOylation sheds light on its potential as a biomarker for disease progression and as a therapeutic target. The advancements in recombinant protein technology have facilitated the large-scale production of SENP1, allowing for in-depth structural and functional analyses. This research not only enhances our understanding of SENP1's role in cellular processes but also paves the way for developing innovative strategies to modulate its activity in pathological conditions, highlighting the significance of SENP1 in both basic and applied biomedical research.
