Analytical Data
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基因名
CLCN2
- Application
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别名
Chloride Channel 2; Chloride channel protein 2; Chloride channel; voltage sensitive 2; CIC 2; CIC2; ClC-2; CLC2; Clcn2; CLCN2_HUMAN
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种属
Human
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表达系统
E. coli
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标签
GST-tag at N-terminal
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
P51788
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表达区间
38-387aa
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氨基酸序列
TVSTAVIVFELTGQIAHILPVMIVVILANAVAQSLQPSLYDSIIRIKKLPYLPELGWGRHQQYRVRVEDIMVRDVPHVALSCTFRDLRLALHRTKGRMLALVESPESMILLGSIERSQVVALLGAQLSPARRRQHMQERRATQTSPLSDQEGPPTPEASVCFQVNTEDSAFPAARGETHKPLKPALKRGPSVTRNLGESPTGSAESAGIALRSLFCGSPPPEAASEKLESCEKRKLKRVRISLASDADLEGEMSPEETHTIFSLLGVDHAYVTSIGRLIGIVTLKELRKAIEGSVTAQGVKVRPPLASFRDSATSSSDTETTEVHALWGPHSRHGLPREGSPSDSDDKCQ
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分子量
64.24 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
CLCN2, a member of the chloride channel family, plays a crucial role in maintaining cellular ion homeostasis and has been implicated in various physiological processes, including neuronal excitability and the regulation of transepithelial transport. Mutations in the CLCN2 gene have been linked to several neurological disorders, making it a subject of intense research. The ability to study CLCN2 through recombinant protein expression has opened new avenues for understanding its structure-function relationships, ion conduction mechanisms, and potential pharmacological interventions. By producing and purifying CLCN2 as a recombinant protein, researchers can perform functional assays, electrophysiological studies, and crystallography to unveil the molecular basis of its action. This research is vital not only for illuminating the underlying causes of CLCN2-related pathologies but also for developing targeted therapies that may alleviate symptoms associated with these disorders. Furthermore, the study of CLCN2 contributes to the broader understanding of chloride channels in health and disease, offering insights into their regulatory roles in various tissues and potential therapeutic targets for related conditions.
