Analytical Data
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Gene name
SASH3
- Application
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Alternative Names
1200013B08Rik; 753P9; AW413946; CXorf9; HACS2; MGC189506; Novel SH3 and SAM domain containing protein; OTTMUSP00000019111; RGD1560293; RP23-351G20.2; SAM and SH3 domain containing 3; SAM and SH3 domain containing protein 3; SAM and SH3 domain-containing protein 3; SASH3; SASH3_HUMAN; SH3 protein expressed in lymphocytes homolog; SH3D6C; SLY
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
O75995
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Expression Region
1-380 aa
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AA Sequence
MLRRKPSNAS EKEPTQKKKL SLQRSSSFKD FAKSKPSSPV VSEKEFNLDD NIPEDDSGVP TPEDAGKSGK KLGKKWRAVI SRTMNRKMGK MMVKALSEEM ADTLEEGSAS PTSPDYSLDS PGPEKMALAF SEQEEHELPV LSRQASTGSE LCSPSPGSGS FGEEPPAPQY TGPFCGRARV HTDFTPSPYD HDSLKLQKGD VIQIIEKPPV GTWLGLLNGK VGSFKFIYVD VLPEEAVGHA RPSRRQSKGK RPKPKTLHEL LERIGLEEHT STLLLNGYQT LEDFKELRET HLNELNIMDP QHRAKLLTAA ELLLDYDTGS EEAEEGAESS QEPVAHTVSE PKVDIPRDSG CFEGSESGRD DAELAGTEEQ LQGLSLAGAP
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Molecular Weight
41.5 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
SASH3, a member of the SASH (SAM and SH3) family of proteins, has gained attention in recent years due to its potential roles in various cellular processes, including immune response, cell signaling, and regulation of gene expression. Initially identified through its interaction with Src homology 3 (SH3) domains, SASH3 is implicated in the modulation of pathways critical for cell proliferation and differentiation. Research has revealed that SASH3 may play a key role in T cell development and function, suggesting its importance in immune system regulation. Additionally, its expression patterns in different tissues and cell types indicate that SASH3 might have diverse functions, potentially influencing tumor biology and pathogenesis. The recombinant expression of SASH3 protein has facilitated in-depth studies into its structure and function, offering insights into its molecular mechanisms and interactions with other proteins. As researchers continue to dissect its roles in both health and disease, SASH3 emerges as a potential biomarker or therapeutic target, underscoring the significance of understanding its biological functions and the implications of SASH3 dysregulation in various pathological conditions.
