Analytical Data
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基因名
PTPN11
- Application
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别名
PTPN11；SLAMF5；SLAM family member 5
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q06124
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表达区间
2-593aa
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氨基酸序列
TSRRWFHPNITGVEAENLLLTRGVDGSFLARPSKSNPGDFTLSVRRNGAVTHIKIQNTGDYYDLYGGEKFATLAELVQYYMEHHGQLKEKNGDVIELKYPLNCADPTSERWFHGHLSGKEAEKLLTEKGKHGSFLVRESQSHPGDFVLSVRTGDDKGESNDGKSKVTHVMIRCQELKYDVGGGERFDSLTDLVEHYKKNPMVETLGTVLQLKQPLNTTRINAAEIESRVRELSKLAETTDKVKQGFWEEFETLQQQECKLLYSRKEGQRQENKNKNRYKNILPFDHTRVVLHDGDPNEPVSDYINANIIMPEFETKCNNSKPKKSYIATQGCLQNTVNDFWRMVFQENSRVIVMTTKEVERGKSKCVKYWPDEYALKEYGVMRVRNVKESAAHDYTLRELKLSKVGQGNTERTVWQYHFRTWPDHGVPSDPGGVLDFLEEVHHKQESIMDAGPVVVHCSAGIGRTGTFIVIDILIDIIREKGVDCDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHYIETLQRRIEEEQKSKRKGHEYTNIKYSLADQTSGDQSPLPPCTPTPPCAEMREDSARVYENVGLMQQQKSFR
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分子量
72.0 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
PTPN11, also known as SHP-2, is a protein tyrosine phosphatase that plays a crucial role in various cellular processes, including cell growth, differentiation, and survival. Dysregulation of PTPN11 has been implicated in several human diseases, particularly in congenital disorders and cancers. Mutations in PTPN11 are associated with Noonan syndrome and juvenile myeloid leukemia, highlighting its significance in development and oncogenesis. As a signaling protein, PTPN11 acts downstream of receptor tyrosine kinases and non-receptor tyrosine kinases, facilitating the transduction of growth factor signals and influencing pathways such as Ras/MAPK. Given its central role in these signaling networks, recombinant PTPN11 has become a valuable tool for studying its biochemical properties, enzymatic activity, and interaction with other signaling molecules. Furthermore, the development of PTPN11 inhibitors is an emerging area of interest in therapeutic research, aiming to target its pathological activation in cancer and other diseases. Understanding PTPN11 through recombinant protein studies can provide insights into the molecular mechanisms underlying its function and the potential for targeted interventions in related disorders.
