Analytical Data
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基因名
PTPN2
- Application
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别名
PTPN2；KIAA0387；Receptor-type tyrosine-Protein phosphatase N2
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
P17706
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表达区间
1-415aa
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氨基酸序列
MPTTIEREFE ELDTQRRWQP LYLEIRNESH DYPHRVAKFP ENRNRNRYRD VSPYDHSRVK LQNAENDYIN ASLVDIEEAQ RSYILTQGPL PNTCCHFWLM VWQQKTKAVV MLNRIVEKES VKCAQYWPTD DQEMLFKETG FSVKLLSEDV KSYYTVHLLQ LENINSGETR TISHFHYTTW PDFGVPESPA SFLNFLFKVR ESGSLNPDHG PAVIHCSAGI GRSGTFSLVD TCLVLMEKGD DINIKQVLLN MRKYRMGLIQ TPDQLRFSYM AIIEGAKCIK GDSSIQKRWK ELSKEDLSPA FDHSPNKIMT EKYNGNRIGL EEEKLTGDRC TGLSSKMQDT MEENSESALR KRIREDRKAT TAQKVQQMKQ RLNENERKRK RWLYWQPILT KMGFMSVILV GAFVGWTLFF QQNAL
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
PTPN2, or Protein Tyrosine Phosphatase Non-Receptor Type 2, is a critical enzyme that plays a significant role in various cellular processes, including cell signaling, proliferation, and differentiation. Research has shown that PTPN2 is linked to autoimmune diseases, such as type 1 diabetes and rheumatoid arthritis, as well as certain cancers. Its function is primarily to dephosphorylate tyrosine residues on target proteins, thereby regulating signaling pathways that are pivotal for immune response and cellular homeostasis. Given its involvement in these pathological conditions, PTPN2 has emerged as a potential therapeutic target. Recent advancements in recombinant protein technologies have enabled the production of purified PTPN2, facilitating detailed studies of its structure and function. Understanding PTPN2's role at the molecular level can provide insights into its regulatory mechanisms and the pathological processes involved in diseases, paving the way for novel treatment strategies. Further research into the functional dynamics of PTPN2, including its interactions with various signaling partners, could lead to the development of targeted therapies aimed at modulating its activity in disease contexts. The growing interest in PTPN2 as a biomarker and therapeutic target underscores the importance of delineating its biological functions and regulatory networks in both health and disease.
