Analytical Data
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Gene name
DLL1
- Application
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Alternative Names
DLL1；Delta-like Protein 1
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
O00548
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Expression Region
22-543aa
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AA Sequence
SGVFELKLQEFVNKKGLLGNRNCCRGGAGPPPCACRTFFRVCLKHYQASV SPEPPCTYGSAVTPVLGVDSFSLPDGGGADSAFSNPIRFPFGFTWPGTFS LIIEALHTDSPDDLATENPERLISRLATQRHLTVGEEWSQDLHSSGRTDL KYSYRFVCDEHYYGEGCSVFCRPRDDAFGHFTCGERGEKVCNPGWKGPYC TEPICLPGCDEQHGFCDKPGECKCRVGWQGRYCDECIRYPGCLHGTCQQP WQCNCQEGWGGLFCNQDLNYCTHHKPCKNGATCTNTGQGSYTCSCRPGYT GATCELGIDECDPSPCKNGGSCTDLENSYSCTCPPGFYGKICELSAMTCA DGPCFNGGRCSDSPDGGYSCRCPVGYSGFNCEKKIDYCSSSPCSNGAKCV DLGDAYLCRCQAGFSGRHCDDNVDDCASSPCANGGTCRDGVNDFSCTCPP GYTGRNCSAPVSRCEHAPCHNGATCHERGHRYVCECARGYGGPNCQFLLP ELPPGPAVVDLTEKLEGQGGPF
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
DLL1 (Delta-like ligand 1) is a crucial member of the Notch signaling pathway, which plays a vital role in various biological processes, including cell differentiation, proliferation, and apoptosis. The importance of DLL1 in development and tissue homeostasis has spurred extensive research into its functions and mechanisms. Aberrant Notch signaling, often involving DLL1, is implicated in several diseases, including cancer, where it can influence tumor growth and metastasis. As a result, DLL1 has emerged as a potential therapeutic target for cancer treatment. Furthermore, the ability to produce recombinant DLL1 protein facilitates in-depth studies of its structure and function. Research involving DLL1 recombinant protein can provide insights into the modulation of the Notch pathway, offering a foundation for the development of targeted therapies. Recent advancements in techniques for protein expression and purification have enabled researchers to generate high-quality DLL1 proteins for functional assays, thereby enhancing our understanding of the ligand's role in normal physiology and disease states. This growing body of knowledge highlights DLL1 as not only a key player in developmental biology but also as a promising candidate for novel therapeutic strategies.
