Analytical Data
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Gene name
RTCD1
- Application
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Alternative Names
RTCA; RPC; RPC1; RTC1; RTCD1; RNA 3'-terminal phosphate cyclase; RNA cyclase; RNA-3'-phosphate cyclase; EC 6.5.1.4; RNA terminal phosphate cyclase domain-containing protein 1; RTC domain-containing protein 1
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
O00442
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Expression Region
1-366 aa
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AA Sequence
MAGPRVEVDG SIMEGGGQIL RVSTALSCLL GLPLRVQKIR AGRSTPGLRP QHLSGLEMIR DLCDGQLEGA EIGSTEITFT PEKIKGGIHT ADTKTAGSVC LLMQVSMPCV LFAASPSELH LKGGTNAEMA PQIDYTVMVF KPIVEKFGFI FNCDIKTRGY YPKGGGEVIV RMSPVKQLNP INLTERGCVT KIYGRAFVAG VLPFKVAKDM AAAAVRCIRK EIRDLYVNIQ PVQEPKDQAF GNGNGIIIIA ETSTGCLFAG SSLGKRGVNA DKVGIEAAEM LLANLRHGGT VDEYLQDQLI VFMALANGVS RIKTGPVTLH TQTAIHFAEQ IAKAKFIVKK SEDEEDAAKD TYIIECQGIG MTNPNL
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Molecular Weight
39.3 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
RTCD1, or RNA terminal phosphate cyclase domain-containing protein 1, has garnered attention in recent years due to its potential roles in RNA metabolism and cellular stress responses. Initially identified in various eukaryotic organisms, RTCD1 is believed to be involved in RNA modification processes, particularly in the formation of cyclic phosphates at the 5' end of RNA molecules, which is crucial for RNA stability, translation, and degradation. Moreover, recent studies have suggested that RTCD1 may play a significant role in the cellular response to environmental stressors, possibly influencing pathways related to cell survival and apoptosis. Its involvement in these processes highlights its significance in various biological functions, including gene expression regulation and the maintenance of cellular integrity under stress. As researchers continue to explore the structural and functional dynamics of RTCD1, its potential implications in health and disease, particularly in cancer and neurodegenerative disorders, are becoming increasingly evident. Understanding the mechanisms by which RTCD1 operates could pave the way for novel therapeutic strategies targeting RNA metabolism and stress response pathways, ultimately contributing to advancements in molecular biology and medicine.
