Analytical Data
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基因名
IL3RA
- Application
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别名
IL3RA；IL3R；Interleukin-3 receptor subunit alpha
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
P26951
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表达区间
19-302aa
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氨基酸序列
TKEDPNPPITNLRMKAKAQQLTWDLNRNVTDIECVKDADYSMPAVN NS YCQFGAISLCEVTNYTVRVANPPFSTWILFPENSGKPWAGAENL TCWI HDVDFLSCSWAVGPGAPADVQYDLYLNVANRRQQYECLHYKT DAQGTR IGCRFDDISRLSSGSQSSHILVRGRSAAFGIPCTDKFVVF SQIEILTP PNMTAKCNKTHSFMHWKMRSHFNRKFRYELQIQKRMQP VITEQVRDRT SFQLLNPGTYTVQIRARERVYEFLSAWSTPQRFECD QEEGANTRGGRV DGIQWIPKVDKKVEPKSCDKTHTCPPCPAPELLG GPSVFLFPPKPKDT LMISRTPEVTCVVVDVSHEDPEVKFNWYVDGV EVHNAKTKPREEQYNS TYRVVSVLTVLHQDWLNGKEYKCRVSNKAL PAPIEKTISKAKGQPREP QVYTLPPSRDELTKNQVSLTCLVKGFYP SDIAVEWESNGQPENNYKTT PPVLDSDGSFFLYSKLTVDKSRWQQG NVFSCSVMHEALHNHYTQKSLS LSPGK
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
IL3RA, or Interleukin-3 receptor alpha, is a critical component of the interleukin-3 signaling pathway, which plays a vital role in hematopoiesis, immune response, and various allergic reactions. This receptor exists in two primary forms: a low-affinity receptor and a high-affinity receptor when combined with the IL-3 cytokine and the common beta chain. Research into IL3RA has garnered significant attention due to its implications in various hematological malignancies, including acute myeloid leukemia (AML) and certain forms of lymphoma, where alterations in its expression can contribute to disease progression and therapeutic resistance. Recombinant IL3RA protein has been developed to facilitate studies on receptor-ligand interactions, signaling pathways, and potential therapeutic applications. Furthermore, understanding the structural and functional properties of IL3RA is crucial for elucidating its role in normal and pathological immune functions. The recombinant protein is also being explored for its potential in immunotherapy, aiming to enhance cytokine responses in immune cells and improve treatments for cancer and other immune-related disorders. Overall, the study of IL3RA recombinant protein is essential for developing targeted therapies and advancing our understanding of immune regulation.
