Analytical Data
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基因名
IFNGR2
- Application
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别名
IFNGR2；Interferon gamma receptor 1
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
P38484
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表达区间
1-337aa
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氨基酸序列
MRPTLLWSLLLLLGVFAAAAAAPPDPLSQLPAPQHPKIRLYNAEQVLSWEPVALSNSTRPVVYQVQFKYTDSKWFTADIMSIGVNCTQITATECDFTAASPSAGFPMDFNVTLRLRAELGALHSAWVTMPWFQHYRNVTVGPPENIEVTPGEGSLIIRFSSPFDIADTSTAFFCYYVHYWEKGGIQQVKGPFRSNSISLDNLKPSRVYCLQVQAQLLWNKSNIFRVGHLSNISCYETMADASTELQQVILISVGTFSLLSVLAGACFFLVLKYRGLIKYWFHTPPSIPLQIEEYLKDPTQPILEALDKDSSPKDDVWDSVSIISFPEKEQEDVLQTL
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
Interferon gamma receptor 2 (IFNGR2) is a crucial component of the interferon gamma signaling pathway, playing a significant role in immune response regulation. It partners with IFNGR1 to form the functional receptor that mediates the effects of interferon-gamma, a key cytokine in innate and adaptive immunity. Dysfunctions or mutations in IFNGR2 can lead to severe immunodeficiencies, notably Mendelian Susceptibility to Mycobacterial Disease (MSMD), characterized by increased susceptibility to mycobacterial infections. Due to its important biological functions and implications in various diseases, researchers have focused on developing recombinant IFNGR2 proteins. These recombinant proteins serve as significant tools for studying the receptor's structure-function relationship, signaling mechanisms, and potential therapeutic interventions. By characterizing IFNGR2 in vitro and in vivo, scientists aim to understand how alterations in this receptor contribute to immune disorders and explore avenues for targeted therapies. The generation of recombinant IFNGR2 proteins is crucial for drug development, allowing for the design of novel therapies that can enhance immune responses, offering promising strategies for treating infectious diseases and autoimmune disorders. This research not only advances our understanding of the immune system but also opens new frontiers in personalized medicine, with the potential to improve outcomes for patients suffering from related immunological conditions.
