Analytical Data
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Gene name
PROS1
- Application
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Alternative Names
PROS1；PROS；Vitamin K-dependent Protein S
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
P07225
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Expression Region
42-676aa
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AA Sequence
ANSLLEETKQGNLERECIEELCNKEEAREVFENDPETDYFYPKYLVCLRSFQTGLFTAARQSTNAYPDLRSCVNAIPDQCSPLPCNEDGYMSCKDGKASFTCTCKPGWQGEKCEFDINECKDPSNINGGCSQICDNTPGSYHCSCKNGFVMLSNKKDCKDVDECSLKPSICGTAVCKNIPGDFECECPEGYRYNLKSKSCEDIDECSENMCAQLCVNYPGGYTCYCDGKKGFKLAQDQKSCEVVSVCLPLNLDTKYELLYLAEQFAGVVLYLKFRLPEISRFSAEFDFRTYDSEGVILYAESIDHSAWLLIALRGGKIEVQLKNEHTSKITTGGDVINNGLWNMVSVEELEHSISIKIAKEAVMDINKPGPLFKPENGLLETKVYFAGFPRKVESELIKPINPRLDGCIRSWNLMKQGASGIKEIIQEKQNKHCLVTVEKGSYYPGSGIAQFHIDYNNVSSAEGWHVNVTLNIRPSTGTGVMLALVSGNNTVPFAVSLVDSTSEKSQDILLSVENTVIYRIQALSLCSDQQSHLEFRVNRNNLELSTPLKIETISHEDLQRQLAVLDKAMKAKVATYLGGLPDVPFSATPVNAFYNGCMEVNINGVQLDLDEAISKHNDIRAHSCPSVWKKTKNS
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Molecular Weight
86.6kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
PROS1, or Protein S, is a vitamin K-dependent plasma glycoprotein known for its crucial role in the regulation of coagulation and the maintenance of hemostatic balance. It acts as a cofactor for the activated protein C (APC) in the inactivation of coagulation factors Va and VIIIa, thereby playing a pivotal role in preventing excessive clot formation. The study of recombinant PROS1 has gained significance due to its potential therapeutic applications in managing coagulation disorders, particularly in patients with Protein S deficiency, which can lead to thrombosis and other serious complications. Additionally, the characterization and production of recombinant PROS1 allow researchers to investigate its functional properties, structural features, and interaction dynamics with other coagulation factors and inhibitors. This research is also crucial for understanding the broader implications of protein S in vascular biology and inflammation. Advances in recombinant DNA technology have facilitated the efficient production of functional PROS1, enabling detailed studies on its biophysical properties and its role in pathogenic mechanisms. Furthermore, ongoing research aims to explore the therapeutic benefits of recombinant PROS1 in clinical settings, including its potential use in anticoagulant therapy and as a biomarker for thrombotic risk assessment. Understanding and harnessing the properties of recombinant PROS1 may contribute to the development of novel strategies for preventing and treating coagulation disorders, ultimately improving patient outcomes in thrombosis management.
