Analytical Data
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基因名
CCRL1
- Application
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别名
ACKR4; CCBP2; CCR11; CCRL1; VSHK1; Atypical chemokine receptor 4; C-C chemokine receptor type 11; C-C CKR-11; CC-CKR-11; CCR-11; CC chemokine receptor-like 1; CCX CKR
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q9NPB9
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表达区间
1-350aa
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氨基酸序列
MALEQNQSTDYYYEENEMNGTYDYSQYELICIKEDVREFAKVFLPVFLTIVFVIGLAGNSMVVAIYAYYKKQRTKTDVYILNLAVADLLLLFTLPFWAVNAVHGWVLGKIMCKITSALYTLNFVSGMQFLACISIDRYVAVTKVPSQSGVGKPCWIICFCVWMAAILLSIPQLVFYTVNDNARCIPIFPRYLGTSMKALIQMLEICIGFVVPFLIMGVCYFITARTLMKMPNIKISRPLKVLLTVVIVFIVTQLPYNIVKFCRAIDIIYSLITSCNMSKRMDIAIQVTESIALFHSCLNPILYVFMGASFKNYVMKVAKKYGSWRRQRQSVEEFPFDSEGPTEPTSTFSI
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分子量
39.9 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
CCRL1 (Chemokine C-C motif receptor-like 1) is a G protein-coupled receptor that has gained attention in immunology and cancer research due to its unique expression pattern and potential functions in regulating immune responses. Initially identified as a receptor for various chemokines, CCRL1 is involved in modulating the migration and activation of immune cells, particularly in inflammatory and lymphoid tissues. Its role in the immune system is further highlighted by its interaction with various ligands that influence both innate and adaptive immunity. Recent studies have suggested that CCRL1 may play a significant role in tumor microenvironments, affecting the infiltration of immune cells and thereby influencing cancer progression. The recombinant protein of CCRL1 enables researchers to better understand its structure-function relationships and provides a tool for investigating its role in cellular signaling pathways. This research is pivotal for elucidating the therapeutic potential of CCRL1 in immune-related disorders and cancer, paving the way for the development of novel immunotherapies targeting CCRL1 to enhance anti-tumor immunity and improve clinical outcomes. Thus, the functional characterization of CCRL1 and the generation of its recombinant protein form are essential steps in uncovering its biological significance and potential applications in biomedicine.
