Analytical Data
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Gene name
SLC3A2
- Application
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Alternative Names
SLC3A2；MDU1；Amino acid transporter heavy chain SLC3A2
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
P08195
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Expression Region
206-630aa
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AA Sequence
RAPRCRELPAQKWWHTGALYRIGDLQAFQGHGAGNLAGLKGRLDYLSSLK VKGLVLGPIHKNQKDDVAQTDLLQIDPNFGSKEDFDSLLQSAKKKSIRVI LDLTPNYRGENSWFSTQVDTVATKVKDALEFWLQAGVDGFQVRDIENLKD ASSFLAEWQNITKGFSEDRLLIAGTNSSDLQQILSLLESNKDLLLTSSYL SDSGSTGEHTKSLVTQYLNATGNRWCSWSLSQARLLTSFLPAQLLRLYQL MLFTLPGTPVFSYGDEIGLDAAALPGQPMEAPVMLWDESSFPDIPGAVSA NMTVKGQSEDPGSLLSLFRRLSDQRSKERSLLHGDFHAFSAGPGLFSYIR HWDQNERFLVVLNFGDVGLSAGLQASDLPASASLPAKADLLLSTQPGREE GSPLELERLKLEPHEGLLLRFPYAAVDHHHHHH
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Molecular Weight
48 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
SLC3A2, also known as CD98 or 4F2hc, is a type II membrane protein that plays a crucial role in amino acid transport and cell signaling. It functions as a heavy chain that dimerizes with various light chains of amino acid transporters, facilitating the uptake of large neutral amino acids and contributing to cellular nutrient sensing. The dysregulation of SLC3A2 is implicated in various pathological conditions, including cancer, obesity, and metabolic disorders, as it regulates cellular growth and survival by modulating amino acid availability. Research into recombinant SLC3A2 protein focuses on its structural and functional properties, aiming to elucidate its role in transporter activity and its interactions with other proteins. By producing and studying recombinant SLC3A2, scientists seek to provide insights into its mechanisms in nutrient transport and signaling pathways, potentially leading to novel therapeutic strategies for diseases linked to amino acid transport dysregulation. Understanding SLC3A2’s function at the molecular level is also essential for exploring its involvement in the development of drug resistance in cancer therapy, highlighting its significance in both basic and translational research.
