Analytical Data
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Gene name
NCF2
- Application
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Alternative Names
NCF2；NOXA2；P67PHOX；Neutrophil cytosol factor 2
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
P19878
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Expression Region
1-526aa
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AA Sequence
MSLVEAISLWNEGVLAADKKDWKGALDAFSAVQDPHSRICFNIGCMYTIL KNMTEAEKAFTRSINRDKHLAVAYFQRGMLYYQTEKYDLAIKDLKEALIQ LRGNQLIDYKILGLQFKLFACEVLYNIAFMYAKKEEWKKAEEQLALATSM KSEPRHSKIDKAMECVWKQKLYEPVVIPVGRLFRPNERQVAQLAKKDYLG KATVVASVVDQDSFSGFAPLQPQAAEPPPRPKTPEIFRALEGEAHRVLFG FVPETKEELQVMPGNIVFVLKKGNDNWATVMFNGQKGLVPCNYLEPVELR IHPQQQPQEESSPQSDIPAPPSSKAPGRPQLSPGQKQKEEPKEVKLSVPM PYTLKVHYKYTVVMKTQPGLPYSQVRDMVSKKLELRLEQTKLSYRPRDSN ELVPLSEDSMKDAWGQVKNYCLTLWCENTVGDQGFPDEPKESEKADANNQ TTEPQLKKGSQVEALFSYEATQPEDLEFQEGDIILVLSKVNEEWLEGECK GKVGIFPKVFVEDCATTDLESTRREV
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Molecular Weight
84 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
NCF2, also known as the Neutrophil Cytosolic Factor 2, is a crucial component of the NADPH oxidase complex, which plays a significant role in the respiratory burst of phagocytes. This complex is vital for the immune response, as it generates reactive oxygen species (ROS) that help to kill invading pathogens. Research into NCF2 is driven by its implications in various diseases, including chronic granulomatous disease (CGD), a genetic disorder characterized by recurrent infections due to a defect in ROS production. Understanding the structure and function of NCF2 can provide insights into its regulation and interaction with other subunits of the NADPH oxidase complex. Furthermore, researchers are investigating the potential of NCF2 as a therapeutic target, given its central role in inflammation and immune responses. The study of NCF2 recombinant proteins allows for the exploration of its biochemical properties, interaction networks, and effects on ROS generation, thus contributing to the development of innovative treatment strategies for immune-related disorders. Additionally, NCF2 has been implicated in diverse cellular processes beyond immunity, including cell signaling and apoptosis, highlighting its multifaceted roles in cellular biology. Overall, the investigation of NCF2 and its recombinant forms is a dynamic field that holds promise for advancing our understanding of innate immunity and developing novel therapeutic approaches for related conditions.
