Analytical Data
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Gene name
NRP1
- Application
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Alternative Names
NRP1；NRP；VEGF165R；Neuropilin-1
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
O14786
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Expression Region
22-644aa
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AA Sequence
FRNDKCGDTIKIESPGYLTSPGYPHSYHPSEKCEWLIQAPDPYQRIMINFNPHFDLEDRDCKYDYVEVFDGENENGHFRGKFCGKIAPPPVVSSGPFLFIKFVSDYETHGAGFSIRYEIFKRGPECSQNYTTPSGVIKSPGFPEKYPNSLECTYIVFVPKMSEIILEFESFDLEPDSNPPGGMFCRYDRLEIWDGFPDVGPHIGRYCGQKTPGRIRSSSGILSMVFYTDSAIAKEGFSANYSVLQSSVSEDFKCMEALGMESGEIHSDQITASSQYSTNWSAERSRLNYPENGWTPGEDSYREWIQVDLGLLRFVTAVGTQGAISKETKKKYYVKTYKIDVSSNGEDWITIKEGNKPVLFQGNTNPTDVVVAVFPKPLITRFVRIKPATWETGISMRFEVYGCKITDYPCSGMLGMVSGLISDSQITSSNQGDRNWMPENIRLVTSRSGWALPPAPHSYINEWLQIDLGEEKIVRGIIIQGGKHRENKVFMRKFKIGYSNNGSDWKMIMDDSKRKAKSFEGNNNYDTPELRTFPALSTRFIRIYPERATHGGLGLRMELLGCEVEAPTAGPTTPNGNLVDECDDDQANCHSGTGDDFQLTGGTTVLATEKPTVIDSTIQSGIK
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Molecular Weight
98.8 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
NRP1 (Neuropilin-1) is a cell surface receptor that plays a crucial role in various biological processes, including angiogenesis, neuronal development, and immune response. The study of NRP1 has gained significant attention due to its involvement in cancer progression and metastasis, where it facilitates tumor growth and vascularization by enhancing the effects of pro-angiogenic factors like VEGF (Vascular Endothelial Growth Factor). NRP1 has also been implicated in immune regulation, influencing T cell development and function. As a result, the recombinant protein of NRP1 has emerged as a focal point for research aimed at understanding its mechanisms and therapeutic potentials. Scientists are exploring the possibility of targeting NRP1 in cancer therapies to inhibit tumor growth or enhance anti-tumor immune responses. Furthermore, recombinant NRP1 proteins are being utilized in various assays to decipher the receptor's binding affinities and downstream signaling pathways. The production of NRP1 as a recombinant protein allows researchers to generate large quantities for detailed structural and functional studies, paving the way for novel therapeutic strategies against diseases where NRP1 is a critical player. As researchers continue to unravel the complexities of NRP1 interactions and functions, the insights gained may lead to innovative treatments that leverage this receptor's unique properties.
