Analytical Data
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Gene name
CCDC49
- Application
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Alternative Names
Pre-mRNA-splicing factor CWC25 homolog. Coiled-coil domain-containing Protein 49. Spliceosome-associated Protein homolog CWC25
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Species
Human
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Source
E. coli
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Tag
GST-tag at N-terminal
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q9NXE8
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Expression Region
1-425aa
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AA Sequence
MGGGDLNLKKSWHPQTLRNVEKVWKAEQKHEAERKKIEELQRELREERAREEMQRYAEDVGAVKKKEEKLDWMYQGPGGMVNRDEYLLGRPIDKYVFEKMEEKEAGCSSETGLLPGSIFAPSGANSLLDMASKIREDPLFIIRKKEEEKKREVLNNPVKMKKIKELLQMSLEKKEKKKKKEKKKKHKKHKHRSSSSDRSSSEDEHSAGRSQKKMANSSPVLSKVPGYGLQVRNSDRNQGLQGPLTAEQKRGHGMKNHSRSRSSSHSPPRHASKKSTREAGSRDRRSRSLGRRSRSPRPSKLHNSKVNRRETGQTRSPSPKKEVYQRRHAPGYTRKLSAEELERKRQEMMENAKWREEERLNILKRHAKDEEREQRLEKLDSRDGKFIHRMKLESASTSSLEDRVKRNIYSLQRTSVALEKNFMKR
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Molecular Weight
76 KDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
CCDC49 (Coiled-Coil Domain Containing 49) is a protein that has garnered interest in recent years due to its potential involvement in various cellular processes and its implications in human health and disease. Characterized by a coiled-coil structure, CCDC49 is suspected to play a role in the formation of protein complexes, contributing to cellular architecture and signaling pathways. Initial research indicates that CCDC49 may be implicated in cytoskeletal organization, which is crucial for maintaining cell shape and facilitating cellular movement. Moreover, studies have suggested that alterations in CCDC49 expression are associated with certain cancers and developmental disorders, prompting investigations into its function as a potential biomarker or therapeutic target. The recombinant expression of CCDC49 allows researchers to delve deeper into its biological mechanisms, providing a platform for studying its interaction with other proteins and cellular components. As a result, the study of recombinant CCDC49 not only enhances our understanding of its role in normal physiology but also offers insights into its contributions to pathophysiological conditions, making it a significant focus in the field of molecular biology and biomedical research.
