Analytical Data
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基因名
TIMP1
- Application
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别名
TIMP1；CLGI；TIMP；MetalloProteinase inhibitor 1
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
P01033
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表达区间
24-207aa
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氨基酸序列
CTCVPPHPQT AFCNSDLVIR AKFVGTPEVN QTTLYQRYEI KMTKMYKGFQ ALGDAADIRF VYTPAMESVC GYFHRSHNRS EEFLIAGKLQ DGLLHITTCS FVAPWNSLSL AQRRGFTKTY TVGCEECTVF PCLSIPCKLQ SGTHCLWTDQ LLQGSEKGFQ SRHLACLPRE PGLCTWQSLR SQIA
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分子量
21 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
TIMP-1 (Tissue Inhibitor of Metalloproteinases-1) is a key regulatory protein that plays a critical role in the modulation of extracellular matrix (ECM) turnover by inhibiting matrix metalloproteinases (MMPs). MMPs are enzymes involved in the degradation of ECM components, and their dysregulation is linked to various pathological conditions, including cancer metastasis, tissue remodeling, and inflammatory diseases. The study of TIMP-1 has gained significant attention due to its dual role in both inhibiting MMP activity and promoting cell survival, suggesting its potential as a therapeutic target. Increased levels of TIMP-1 have been associated with poor prognosis in several cancers, indicating its involvement in tumor progression and metastasis. Furthermore, understanding the structural and functional properties of recombinant TIMP-1 proteins can provide valuable insights into their mechanisms of action and enable the development of innovative therapeutic interventions. Researchers are exploring recombinant protein production strategies to generate TIMP-1 for both functional studies and potential clinical applications, such as drug design and regenerative medicine. As a result, TIMP-1 continues to be a focal point in studies aimed at unraveling the complexities of ECM dynamics and developing effective treatments for related diseases.
