Analytical Data
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Gene name
CCDC21
- Application
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Alternative Names
CCDC21; Centrosomal Protein of 85 kDa; CEP85; CEP85_HUMAN; Coiled-coil domain containing 21; Coiled-coil domain-containing Protein 21; DKFZp434L0117; DKFZp434P232; FLJ13976
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Species
Human
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Source
E. coli
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Tag
GST-tag at N-terminal
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q6P2H3
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Expression Region
1-762aa
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AA Sequence
MAMQEKYPTEGISHVTSPSSDVIQKGSSLGTEWQTPVISEPFRSRFSRCSSVADSGDTAIGTSCSDIAEDFCSSSGSPPFQPIKSHVTIPTAHVMPSTLGTSPAKPNSTPVGPSSSKLPLSGLAESVGMTRNGDLGAMKHSPGLSRDLMYFSGATGENGIEQSWFPAVGHERQEEARKFDIPSMESTLNQSAMMETLYSDPHHRVRFHNPRTSTSKELYRVLPEAKKAPGSGAVFERNGPHSNSSGVLPLGLQPAPGLSKPLPSQVWQPSPDTWHPREQSCELSTCRQQLELIRLQMEQMQLQNGAICHHPAAFGPSLPILEPAQWISILNSNEHLLKEKELLIDKQRKHISQLEQKVRESELQVHSALLGRPAPFGDVCLLRLQELQRENTFLRAQFAQKTEALSREKIDLEKKLSASEVEVQLIRESLKVALQKHSEEVKKQEERVKGRDKHINNLKKKCQKESEQNREKQQRIETLERYLADLPTLEDHQKQSQQLKDSELKSTELQEKVTELESLLEETQAICREKEIQLESLRQREAEFSSAGHSLQDKQSVEETSGEGPEVEMESWQKRYDSLQKIVEKQQQKMDQLRSQVQSLEQEVAQEEGTSQALREEAQRRDSALQQLRTAVKELSVQNQDLIEKNLTLQEHLRQAQPGSPPSPDTAQLALELHQELASCLQDLQAVCSIVTQRAQGHDPNLSLLLGIHSAQHPETQLDLQKPDVIKRKLEEVQQLRRDIEDLRTTMSDRYAQDMGENCVTQ
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Molecular Weight
112 KDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
CCDC21, or Coiled-Coil Domain Containing 21, is a protein that has garnered attention due to its potential roles in various cellular processes, particularly in cilia formation and function. Cilia are essential cellular organelles involved in signaling pathways and cellular movement, playing crucial roles in development and homeostasis. Dysfunction of ciliary proteins is linked to several diseases, including ciliopathies, which encompass a range of genetic disorders characterized by abnormal cilia structure or function. Understanding the structure and function of CCDC21 is vital for elucidating its role in cilium biology and its implications in health and disease. Recombinant CCDC21 protein has been produced to study its molecular interactions, structural properties, and biochemical functions. By investigating the physiological roles of CCDC21, researchers aim to uncover its contribution to ciliary signaling pathways and its involvement in disease mechanisms. This could potentially lead to the development of therapeutic strategies targeting CCDC21-related disorders. The ongoing research aims to clarify the functional mechanisms of CCDC21 and its interaction with other ciliary proteins, contributing to a deeper understanding of cilia-related diseases and advancing the field of cellular biology.
