Analytical Data
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基因名
KIFBP
- Application
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别名
KIFBP；KBP；KIAA1279；KIF1BP；KIF-binding Protein
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q96EK5
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表达区间
1-621aa
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氨基酸序列
MANVPWAEVCEKFQAALALSRVELHKNPEKEPYKSKYSARALLEEVKALLGPAPEDEDERPEAEDGPGAGDHALGLPAEVVEPEGPVAQRAVRLAVIEFHLGVNHIDTEELSAGEEHLVKCLRLLRRYRLSHDCISLCIQAQNNLGILWSEREEIETAQAYLESSEALYNQYMKEVGSPPLDPTERFLPEEEKLTEQERSKRFEKVYTHNLYYLAQVYQHLEMFEKAAHYCHSTLKRQLEHNAYHPIEWAINAATLSQFYINKLCFMEARHCLSAANVIFGQTGKISATEDTPEAEGEVPELYHQRKGEIARCWIKYCLTLMQNAQLSMQDNIGELDLDKQSELRALRKKELDEEESIRKKAVQFGTGELCDAISAVEEKVSYLRPLDFEEARELFLLGQHYVFEAKEFFQIDGYVTDHIEVVQDHSALFKVLAFFETDMERRCKMHKRRIAMLEPLTVDLNPQYYLLVNRQIQFEIAHAYYDMMDLKVAIADRLRDPDSHIVKKINNLNKSALKYYQLFLDSLRDPNKVFPEHIGEDVLRPAMLAKFRVARLYGKIITADPKKELENLATSLEHYKFIVDYCEKHPEAAQEIEVELELSKEMVSLLPTKMERFRTKMALT
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
KIFBP (Kinesin-Interacting Factor Binding Protein) is a crucial component of the kinesin motor protein family, which plays a significant role in intracellular transport processes. Kinesins are responsible for transporting cellular cargo along microtubules, and KIFBP is known to interact with various kinesins, modulating their activity and helping to ensure proper cellular function. Research into KIFBP has gained momentum due to its potential implications in understanding cellular dynamics, neurodegenerative diseases, and cancer biology. Notably, abnormalities in protein transport mechanisms are often associated with conditions such as Alzheimer's and other neurodegenerative disorders, where KIFBP's regulatory role may contribute to misfolded protein accumulation and disrupted cellular signaling. Additionally, KIFBP's interactions with kinesins could provide insights into cancer cell metastasis, as altered intracellular transport can influence cell movement and growth. The recombinant expression and characterization of KIFBP can enhance our understanding of its structural and functional properties, facilitating the exploration of its role in health and disease. Advances in techniques such as X-ray crystallography, cryo-electron microscopy, and functional assays are pivotal in elucidating the molecular mechanisms underlying KIFBP's function. Overall, studying KIFBP as a recombinant protein opens avenues for therapeutic interventions and highlights its significance in the intricate networks governing cellular processes.
