Analytical Data
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Gene name
CACNB3
- Application
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Alternative Names
CAB3; CACB3_HUMAN; Cacnb3; CACNLB3; Calcium channel voltage dependent beta 3 subunit; Calcium channel voltage-dependent subunit beta 3; FLJ58949; Voltage-dependent L-type calcium channel subunit beta-3
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Species
Human
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Source
E. coli
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Tag
GST-tag at N-terminal
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
P54284
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Expression Region
1-484aa
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AA Sequence
MYDDSYVPGF EDSEAGSADS YTSRPSLDSD VSLEEDRESA RREVESQAQQ QLERAKHKPV AFAVRTNVSY CGVLDEECPV QGSGVNFEAK DFLHIKEKYS NDWWIGRLVK EGGDIAFIPS PQRLESIRLK QEQKARRSGN PSSLSDIGNR RSPPPSLAKQ KQKQAEHVPP YDVVPSMRPV VLVGPSLKGY EVTDMMQKAL FDFLKHRFDG RISITRVTAD LSLAKRSVLN NPGKRTIIER SSARSSIAEV QSEIERIFEL AKSLQLVVLD ADTINHPAQL AKTSLAPIIV FVKVSSPKVL QRLIRSRGKS QMKHLTVQMM AYDKLVQCPP ESFDVILDEN QLEDACEHLA EYLEVYWRAT HHPAPGPGLL GPPSAIPGLQ NQQLLGERGE EHSPLERDSL MPSDEASESS RQAWTGSSQR SSRHLEEDYA DAYQDLYQPH RQHTSGLPSA NGHDPQDRLL AQDSEHNHSD RNWQRNRPWP KDSY
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Molecular Weight
80.9 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
CACNB3 (Calcium Voltage-Gated Channel Auxiliary Subunit Beta-3) is a key component of voltage-gated calcium channels (VGCCs), which play essential roles in various physiological processes, including muscle contraction, neurotransmitter release, and cardiac function. The protein is known for its regulatory influence on the calcium channel's biophysical properties and localization, significantly impacting cellular calcium homeostasis. Abnormalities in CACNB3 have been associated with various neurological and cardiovascular disorders, making it a subject of interest in medical research. The study of CACNB3 recombinant proteins enables researchers to investigate its structural and functional characteristics, facilitating the understanding of its role in calcium signaling pathways. By expressing and purifying CACNB3 in different systems, scientists can examine how modifications, such as post-translational modifications or substitutions, affect its interaction with other channel subunits and auxiliary proteins. Additionally, studying CACNB3 in the context of disease models allows for the exploration of potential therapeutic targets and the development of calcium channel modulators. Thus, research on CACNB3 recombinant proteins holds promise for advancing our understanding of calcium channel physiology and its implications in health and disease.
