Analytical Data
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Gene name
REC14
- Application
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Alternative Names
Meiotic recombination REC14 protein homolog; REC14; Recombination protein REC14; Ski8; SKI8 homolog; WD repeat containing protein 61; WD repeat domain 61; WD repeat-containing protein 61; WDR 61; wdr61; WDR61_HUMAN
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q9GZS3
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Expression Region
2-305 aa
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AA Sequence
TNQYGILFK QEQAHDDAIW SVAWGTNKKE NSETVVTGSL DDLVKVWKWR DERLDLQWSL EGHQLGVVSV DISHTLPIAA SSSLDAHIRL WDLENGKQIK SIDAGPVDAW TLAFSPDSQY LATGTHVGKV NIFGVESGKK EYSLDTRGKF ILSIAYSPDG KYLASGAIDG IINIFDIATG KLLHTLEGHA MPIRSLTFSP DSQLLVTASD DGYIKIYDVQ HANLAGTLSG HASWVLNVAF CPDDTHFVSS SSDKSVKVWD VGTRTCVHTF FDHQDQVWGV KYNGNGSKIV SVGDDQEIHI YDCPI
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Molecular Weight
33.5 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
REC14 is a critical protein involved in the regulation of various cellular processes, particularly in the context of DNA repair and replication. Its significance has gained attention due to the increasing awareness of the role of DNA damage response mechanisms in maintaining genomic stability and preventing cancer. Research on REC14 has revealed its potential involvement in the homologous recombination repair pathway, which is essential for repairing double-strand breaks in DNA. Understanding REC14's structure and function can provide insights into its mechanisms of action and its interactions with other proteins involved in the DNA damage response. Additionally, aberrations in the pathways regulated by REC14 have been linked to various diseases, including cancer, making this protein a potential target for therapeutic strategies. Therefore, studying the recombinant forms of REC14 can enhance our understanding of its role in cellular repair processes and its implications in disease, positioning it as a significant focus in molecular biology and cancer research. This research not only contributes to basic science but also opens avenues for targeted therapies that could exploit the mechanisms of REC14 in tumor cells, leading to more effective cancer treatments.
