Analytical Data
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基因名
C9orf43
- Application
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别名
C9orf43; Chromosome 9 open reading frame 43; CI043_HUMAN; Hypothetical Protein LOC257169; MGC17358; OTTHUMP00000021960; Uncharacterized Protein C9orf43
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种属
Human
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表达系统
E. coli
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标签
GST-tag at N-terminal
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q8TAL5
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表达区间
1-461aa
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氨基酸序列
MDLPDESQWD ETTCGLAVCQ HPQCWATIRR IERGHPRILG SSCKTPLDAE DKLPVLTVVD ILDSGFAAHH LPECTFTKAH SLLSQSSKFY SKFHGRPPKG LPDKSLINCT NRLPKFPVLN LNETQLPCPE DVRNMVVLWI PEETEIHVSQ HGKKKRKNSA VKSKSFLGLS GNQSAGTRVG TPGMIVPPPT PVQLSEQFSS DFLPLWAQSE ALPQDLLKEL LPGGKQTMLC PEMKIKLAMM KKNLPLEKNR PDSVISSKMF LSIHRLTLER PALRYPERLK KLHNLKTEGY RKQQQRQQQQ QQQQKKVKTP IKKQEAKKKA KSDPGIQSTS HKHPVTTVHD RLYGYRTLPG QNSDMKQQQQ MEKGTTSKQD STERPKMNYY DHADFHHSVK SPELYETEPT NKDISAPVDA VPEAQAARQK KISFNFSEIM ASTGWNSELK LLRILQDTDD EDEEDQSSGA E
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分子量
52.2 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
C9orf43, a gene located on chromosome 9, has garnered attention in recent years due to its potential link to various neurodegenerative diseases, including amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). The reconstitution of C9orf43 protein is critical for understanding its biological functions and its role in disease mechanisms. Research indicates that mutations or aberrant expression of C9orf43 may disrupt cellular processes such as RNA metabolism, protein aggregation, and autophagy, contributing to neuronal degeneration. Furthermore, the protein's interactions with other cellular components and its involvement in stress response pathways suggest that it may play a significant role in maintaining neuronal health. The production and study of recombinant C9orf43 protein facilitate investigations into its structural properties and functional implications, opening pathways for potential therapeutic strategies targeting these neurodegenerative disorders. By elucidating the molecular mechanisms underlying C9orf43-related pathologies, researchers aim to develop biomarkers for early diagnosis and novel treatment modalities, ultimately improving the prognosis for affected individuals.
