Analytical Data
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Gene name
RBM4
- Application
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Alternative Names
dkfzp547k0918; hLark; lark; Lark homolog; lark homologue; mgc75138; RBM4; rbm4 lark; RBM4_HUMAN; RNA binding motif 4; RNA binding motif 4a; RNA-binding motif protein 4; RNA-binding motif protein 4a; RNA-binding protein 4
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q9BWF3
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Expression Region
1-364 aa
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AA Sequence
MVKLFIGNLP REATEQEIRS LFEQYGKVLE CDIIKNYGFV HIEDKTAAED AIRNLHHYKL HGVNINVEAS KNKSKTSTKL HVGNISPTCT NKELRAKFEE YGPVIECDIV KDYAFVHMER AEDAVEAIRG LDNTEFQGKR MHVQLSTSRL RTAPGMGDQS GCYRCGKEGH WSKECPIDRS GRVADLTEQY NEQYGAVRTP YTMSYGDSLY YNNAYGALDA YYKRCRAARS YEAVAAAAAS VYNYAEQTLS QLPQVQNTAM ASHLTSTSLD PYDRHLLPTS GAAATAAAAA AAAAAVTAAS TSYYGRDRSP LRRATAPVPT VGEGYGYGHE SELSQASAAA RNSLYDMARY EREQYADRAR YSAF
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Molecular Weight
40.3 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
The study of RBM4 (RNA-binding motif protein 4) has gained significant interest due to its critical role in various biological processes, particularly in mRNA splicing and regulation. RBM4 is known to interact with multiple RNA molecules and splicing factors, influencing gene expression and cellular functions. Its involvement in alternative splicing makes it a vital player in determining protein diversity and function, especially during development and in response to environmental stimuli. Additionally, RBM4 has been implicated in several diseases, including cancer, neurodegenerative disorders, and cardiovascular conditions, where its dysregulation may lead to aberrant splicing patterns and altered gene expression profiles. Understanding the mechanisms of RBM4 function and its interactions with RNA and other cellular components is crucial for uncovering its roles in health and disease. Recent studies focusing on the recombinant expression of RBM4 have provided valuable insights into its structure-function relationships and the potential therapeutic implications of modulating its activity. By harnessing advanced biotechnological approaches, researchers aim to explore RBM4's intricate regulatory networks and develop strategies for targeting its interactions in disease contexts, ultimately contributing to the advancement of RNA biology and therapeutic interventions.
