Cat: PAX2000-10803

Recombinant Human RBM42 Protein,His

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Analytical Data

  • Gene name

    RBM42

  • Application

    SPRMSTBLIITCELISACELL ASSAYDRUG SCREENING

  • Alternative Names

    RBM42; RNA-binding protein 42; RNA-binding motif protein 42

  • Species

    Human

  • Source

    E. coli

  • Tag

    His tag N-Terminus

  • Purity

    Greater than 90% as determined by SDS-PAGE.

  • Uniprot

    Q9BTD8

  • Expression Region

    2-480 aa

  • AA Sequence

    AGAGPAPGL PGAGGPVVPG PGAGIPGKSG EERLKEMEAE MALFEQEVLG APVPGIPTAV PAVPTVPTVP TVEAMQVPAA PVIRPIIATN TYQQVQQTLE ARAAAAATVV PPMVGGPPFV GPVGFGPGDR SHLDSPEARE AMFLRRAAVA PQRAPILRPA FVPHVLQRAD SALSSAAAGP RPMALRPPHQ ALVGPPLPGP PGPPMMLPPM ARAPGPPLGS MAALRPPLEE PAAPRELGLG LGLGLKEKEE AVVAAAAGLE EASAAVAVGA GGAPAGPAVI GPSLPLALAM PLPEPEPLPL PLEVVRGLLP PLRIPELLSL RPRPRPPRPE PPPGLMALEV PEPLGEDKKK GKPEKLKRCI RTAAGSSWED PSLLEWDADD FRIFCGDLGN EVNDDILARA FSRFPSFLKA KVIRDKRTGK TKGYGFVSFK DPSDYVRAMR EMNGKYVGSR PIKLRKSMWK DRNLDVVRKK QKEKKKLGLR

  • Molecular Weight

    50.4 kDa

  • Endotoxin

    < 1.0 EU per μg protein as determined by the LAL method.

  • Form

    Freeze-dried powder

  • Buffer formulation

    PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.

  • Reconstitution

    Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.

  • Customization

    Site-directed mutagenesis Custom tag design Custom buffer formulation Custom full-length protein production

  • Stability Test

    The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.

  • Storage & Shelf Life

    Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.

  • Shipping

    In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.

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Protein Description

RBM42 (RNA-binding motif protein 42) is a member of the heterogeneous nuclear ribonucleoprotein (hnRNP) family, recognized for its crucial role in RNA processing and regulation. Research into RBM42 has gained momentum due to its involvement in various cellular processes, including splicing, mRNA stability, and translation. Alterations in RBM42 expression levels have been implicated in several diseases, notably in cancer, where it may affect tumorigenesis and metastasis by modulating the expression of key oncogenes and tumor suppressors. Scientists have also focused on studying the structural and functional properties of RBM42 to understand its interactions with RNA and other proteins. The production of recombinant RBM42 protein allows for in-depth biochemical assays and structural analysis, facilitating investigations into its mechanism of action and potential therapeutic implications. Understanding the functional dynamics of RBM42 can pave the way for novel strategies in targeting RNA-binding proteins in disease management, emphasizing the significance of this research in the broader context of molecular biology and medicine.

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