Analytical Data
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Gene name
ILKAP
- Application
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Alternative Names
ILKAP；Integrin-linked kinase-associated serine/threonine phosphatase 2C
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q9H0C8
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Expression Region
1-392aa
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AA Sequence
MDLFGDLPEP ERSPRPAAGK EAQKGPLLFD DLPPASSTDS GSGGPLLFDD LPPASSGDSG SLATSISQMV KTEGKGAKRK TSEEEKNGSE ELVEKKVCKA SSVIFGLKGY VAERKGEREE MQDAHVILND ITEECRPPSS LITRVSYFAV FDGHGGIRAS KFAAQNLHQN LIRKFPKGDV ISVEKTVKRC LLDTFKHTDE EFLKQASSQK PAWKDGSTAT CVLAVDNILY IANLGDSRAI LCRYNEESQK HAALSLSKEH NPTQYEERMR IQKAGGNVRD GRVLGVLEVS RSIGDGQYKR CGVTSVPDIR RCQLTPNDRF ILLACDGLFK VFTPEEAVNF ILSCLEDEKI QTREGKSAAD ARYEAACNRL ANKAVQRGSA DNVTVMVVRI GH
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Molecular Weight
44 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
ILKAP, or Integrin-Linked Kinase-Associated Protein, has garnered significant attention in recent years due to its crucial role in cellular signaling pathways, especially those related to cell adhesion, proliferation, and survival. As a regulator of ILK (Integrin-Linked Kinase), ILKAP modulates various downstream signaling cascades that are integral to maintaining cellular integrity and function. Research has shown that ILKAP is involved in various physiological processes, including tissue development, wound healing, and the response to cellular stress. Aberrant expression or dysfunction of ILKAP has been linked to several pathological conditions, including cancer, where it may contribute to tumor progression and metastasis by influencing cell motility and invasiveness. Furthermore, studies indicate that ILKAP may play a role in the modulation of the inflammatory response and in the regulation of apoptosis. Given its multifaceted functions, there is a growing interest in the therapeutic potential of targeting ILKAP and related pathways in various diseases. Understanding the biochemical properties and regulatory mechanisms of ILKAP is essential for developing novel therapeutic strategies and improving disease outcomes. Therefore, ongoing research efforts are focused on elucidating the structural and functional aspects of ILKAP, as well as its interactions with other key signaling molecules, to pave the way for innovative interventions in diseases where ILKAP dysregulation is implicated.
