Analytical Data
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Gene name
CREB3L1
- Application
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Alternative Names
CREB3L1；DPC4；MADH4；Mothers against decapentaplegic homolog 4
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q96BA8
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Expression Region
396-519aa
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AA Sequence
EFSSGSQTVK EDPLAADGVY TASQMPSRSL LFYDDGAGLW EDGRSTLLPM EPPDGWEINP GGPAEQRPRD HLQHDHLDST HETTKYLSEA WPKDGGNGTS PDFSHSKEWF HDRDLGPNTT IKLS
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Molecular Weight
15 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
CREB3L1, a member of the CREB (cAMP response element-binding protein) family, plays a critical role in regulating cellular stress responses, particularly in the context of the endoplasmic reticulum (ER) and Golgi apparatus function. It is known to be involved in the unfolded protein response (UPR), a cellular process that helps to maintain homeostasis under stress conditions like unfolded proteins, oxidative stress, and viral infections. Mutations or alterations in the expression levels of CREB3L1 have been implicated in various diseases, including metabolic disorders, neurodegenerative diseases, and certain cancers. Research has indicated that CREB3L1 acts as a transcription factor, influencing the expression of genes related to cell survival, apoptosis, and inflammation. Additionally, its interaction with other proteins and regulatory pathways underscores its potential as a therapeutic target. The recombinant expression of CREB3L1 allows for detailed studies of its functional mechanisms and interactions within cellular stress pathways, providing insights into its role in health and disease states. Understanding the structure and function of CREB3L1 through recombinant protein approaches may pave the way for novel therapeutic interventions targeting related diseases while elucidating fundamental biological processes linked to cellular stress responses.
