Analytical Data
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Gene name
RASL11B
- Application
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Alternative Names
RASL11B; Ras-like protein family member 11B
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q9BPW5
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Expression Region
1-248 aa
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AA Sequence
MRLIQNMCTI AEYPAPGNAA ASDCCVGAAG RRLVKIAVVG ASGVGKTALV VRFLTKRFIG DYERNAGNLY TRQVQIEGET LALQVQDTPG IQVHENSLSC SEQLNRCIRW ADAVVIVFSI TDYKSYELIS QLHQHVQQLH LGTRLPVVVV ANKADLLHIK QVDPQLGLQL ASMLGCSFYE VSVSENYNDV YSAFHVLCKE VSHKQQPSST PEKRRTSLIP RPKSPNMQDL KRRFKQALSA KVRTVTSV
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Molecular Weight
27.5 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
RASL11B, a member of the Ras superfamily of small GTPases, has garnered significant attention due to its potential role in various cellular processes, including proliferation, differentiation, and cell migration. Research has indicated that RASL11B may be involved in tumorigenesis and cancer progression, although its precise mechanisms of action remain largely uncharacterized. Notably, the expression of RASL11B has been observed in several human tissues, suggesting its relevance in normal physiological functions as well as disease states. The study of RASL11B as a recombinant protein is essential for elucidating its structure-function relationships, as well as its interactions with downstream effectors and regulatory proteins. By producing RASL11B as a recombinant protein, researchers can employ various biochemical and biophysical techniques to investigate its GTPase activity, binding affinities, and conformational dynamics. Understanding these aspects may not only unveil new pathways involved in cell signaling but also identify potential therapeutic targets for diseases characterized by dysregulated Ras signaling. Overall, the investigation of RASL11B in recombinant form is critical to advancing our knowledge of its biological roles and implications in health and disease, paving the way for novel strategies in cancer therapy and personalized medicine.
