Analytical Data
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基因名
Kim1
- Application
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别名
Kim1；KIM1；TIM1；TIMD1；Hepatitis A virus cellular receptor 1
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种属
Rat
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
O54947
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表达区间
1-307aa
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氨基酸序列
MVQLQVFISGLLLLLPGSVDSYEVVKGVVGHPVTIPCTYSTRGGITTTCWGRGQCPYSSCQNILIWTNGYQVTYRSSGRYNIKGRISEGDVSLTIENSVDSDSGLYCCRVEIPGWFNDQKMTFSLEVKPEIPTSPPTRPTTTRPTTTRPTTISTRSTHVPTSTRVSTSTPTPEQTQTHKPEITTFYAHETTAEVTETPSYTPADWNGTVTSSEEAWNNHTVRIPLRKPQRNPTKGFYVGMSVAALLLLLLASTVVVTRYIIIRKKMGSLSFVAFHVSKSRALQNAAIVHPRAEDNIYIIEDRSRGAE
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
Kim1, also known as kidney injury molecule-1, is a type I transmembrane protein that plays a crucial role in renal pathology. Initially identified as a marker for kidney injury, Kim1 is predominantly expressed in the proximal tubules of the kidney during acute injury and is released into the urine. Research has shown that Kim1 is involved in various cellular processes, including apoptosis, cell proliferation, and inflammation. Its elevated expression serves as a significant indicator of renal damage, making it a valuable biomarker for acute kidney injury (AKI) and related disorders. Furthermore, Kim1’s role extends beyond mere detection, as it is implicated in tubular repair mechanisms and the phagocytosis of apoptotic cells. The exploration of Kim1's structure and function, particularly in the context of its recombinant protein form, has garnered interest in both basic and clinical research. Advances in recombinant DNA technology enable the production of Kim1 at scale, paving the way for potential therapeutic applications, including the development of diagnostic tools and targeted therapies for kidney diseases. Understanding Kim1's molecular interactions and signaling pathways will enhance our knowledge of kidney pathology and lead to innovative strategies for managing renal injuries.
