Analytical Data
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基因名
RANGNRF
- Application
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别名
DKFZp686F02139; HSPC165; HSPC236; MGC110973; MOG 1; MOG1; MOG1 homolog; MOG1_HUMAN; Ran guanine nucleotide release factor; Ran-binding protein MOG1; RanGNRF; RANGRF
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q9HD47
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表达区间
1-186 aa
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氨基酸序列
MEPTRDCPLF GGAFSAILPM GAIDVSDLRP VPDNQEVFCH PVTDQSLIVE LLELQAHVRG EAAARYHFED VGGVQGARAV HVESVQPLSL ENLALRGRCQ EAWVLSGKQQ IAKENQQVAK DVTLHQALLR LPQYQTDLLL TFNQPPPDNR SSLGPENLSP APWSLGDFEQ LVTSLTLHDP NIFGPQ
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分子量
20.4 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
RANGRF (RAN Guanine Nucleotide Release Factor) is a pivotal protein involved in nucleocytoplasmic transport, influencing cellular signaling and communication. Research on RANGRF has gained momentum due to its critical role in regulating the transport of RNA and proteins between the nucleus and cytoplasm, which is essential for maintaining cellular homeostasis and function. Dysregulation of RANGRF has been linked to various diseases, including cancer and neurodegenerative disorders, highlighting its importance in cellular health. The recombinant form of RANGRF is of particular interest in biophysical and biochemical studies, enabling researchers to dissect its structural properties and functional mechanisms. By expressing and purifying RANGRF in host systems, scientists can investigate its interactions with other cellular components, evaluate its enzymatic activities, and examine its role in transport pathways. This research not only provides insights into the basic biology of RANGRF but also offers potential therapeutic targets for modulating its activity in pathological conditions. Overall, the study of RANGRF recombinant proteins is crucial for understanding fundamental cellular processes and developing novel strategies for disease intervention.
