Analytical Data
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Gene name
RANBP3
- Application
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Alternative Names
DKFZp586I1520; Ran binding protein 3; Ran-binding protein 3; RANB3_HUMAN; RanBP3
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q9H6Z4
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Expression Region
1-567 aa
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AA Sequence
MADLANEEKP AIAPPVFVFQ KDKGQKSPAE QKNLSDSGEE PRGEAEAPHH GTGHPESAGE HALEPPAPAG ASASTPPPPA PEAQLPPFPR ELAGRSAGGS SPEGGEDSDR EDGNYCPPVK RERTSSLTQF PPSQSEERSS GFRLKPPTLI HGQAPSAGLP SQKPKEQQRS VLRPAVLQAP QPKALSQTVP SSGTNGVSLP ADCTGAVPAA SPDTAAWRSP SEAADEVCAL EEKEPQKNES SNASEEEACE KKDPATQQAF VFGQNLRDRV KLINESVDEA DMENAGHPSA DTPTATNYFL QYISSSLENS TNSADASSNK FVFGQNMSER VLSPPKLNEV SSDANRENAA AESGSESSSQ EATPEKESLA ESAAAYTKAT ARKCLLEKVE VITGEEAESN VLQMQCKLFV FDKTSQSWVE RGRGLLRLND MASTDDGTLQ SRLVMRTQGS LRLILNTKLW AQMQIDKASE KSIRITAMDT EDQGVKVFLI SASSKDTGQL YAALHHRILA LRSRVEQEQE AKMPAPEPGA APSNEEDDSD DDDVLAPSGA TAAGAGDEGD GQTTGST
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Molecular Weight
60.2 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
RANBP3 (Ran-binding protein 3) is a nuclear protein that plays a crucial role in various cellular processes, including nucleocytoplasmic transport, gene expression regulation, and ribosome biogenesis. Its implications in cancer biology and other diseases have sparked significant interest in understanding its molecular mechanisms. RANBP3 is known to interact with the small GTPase Ran, which is pivotal for the transport of proteins and RNA across the nuclear envelope. Studies have shown that RANBP3 is involved in cellular responses to stress and may influence apoptosis and cell cycle progression. Moreover, abnormal expression or mutations in RANBP3 have been associated with tumorigenesis and poor prognosis in various cancers, making it a potential biomarker for cancer diagnosis and therapy. The recombinant expression of RANBP3 has enabled researchers to explore its structural properties and functional dynamics in greater detail. By producing this protein in a controlled environment, scientists can investigate its interactions with other cellular molecules, providing insights into its role in disease mechanisms. Understanding the functional characteristics of RANBP3 through recombinant protein studies could lead to new therapeutic strategies targeting its pathways in cancer and other related conditions. The need for such research underscores the importance of RANBP3 in cellular biology and its potential as a therapeutic target, highlighting the ongoing investigation into its biological functions and relevance in health and disease.
