Analytical Data
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Gene name
RALGDS
- Application
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Alternative Names
Maxp 1; MAXP1; MGC10823; MGC17344; New ras effector 1; NORE 1; NORE1; NORE1A; NORE1B; Novel Ras effector 1; RAP1 Binding Protein; RAPL; Ras association (RalGDS/AF 6) domain family 5; Ras association (RalGDS/AF 6) domain family member 5; Ras association domain containing family protein 5; Ras association domain-containing protein 5; Ras effector like protein; RASF5_HUMAN; RASSF 3; RASSF 5; RASSF3; RASSF5; Regulator for cell adhesion and polarization enriched in lymphoid tissue; Regulator for cell adhesion and polarization enriched in lymphoid tissues; Tumor suppressor RASSF3
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q8WWW0
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Expression Region
1-265 aa
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AA Sequence
MTVDSSMSSGYCSLDEELEDCFFTAKTTFFRNAQSKHLSKNVCKPVEETQRPPTLQEIKQKIDSYNTREKNCLGMKLSEDGTYTGFIKVHLKLRRPVTVPAGIRPQSIYDAIKEVNLAATTDKRTSFYLPLDAIKQLHISSTTTVSEVIQGLLKKFMVVDNPQKFALFKRIHKDGQVLFQKLSIADRPLYLRLLAGPDTEVLSFVLKENETGEVEWDAFSIPELQNFLTILEKEEQDKIQQVQKKYDKFRQKLEEALRESQGKPG
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Molecular Weight
57.4 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
RALGDS (RAL guanine nucleotide dissociation stimulator) is a critical regulator in the Ral signaling pathway, which plays a vital role in various cellular processes including cell growth, differentiation, and survival. Research into RALGDS has gained momentum due to its implication in cancer biology and its potential as a therapeutic target. Studies have shown that RALGDS activates the RalA and RalB small GTPases, which are involved in oncogenic processes such as cell migration and invasion. Furthermore, alterations in RALGDS expression and function have been observed in several cancer types, underscoring its significance in tumor progression. The recombinant production of RALGDS protein has become a focal point of investigation, as it allows for detailed structural and functional analyses, which are essential for understanding its mechanisms of action. Through the use of recombinant techniques, researchers can produce large quantities of RALGDS for biochemical assays and structural studies, paving the way for the development of small molecules that could inhibit its activity. Furthermore, insights gained from RALGDS studies could contribute to the design of novel therapies aimed at modulating Ral signaling in cancer cells, providing new avenues for treatment strategies. Given the rising interest in targeting Ral signaling pathways, continued research on recombinant RALGDS is not only important for academic understanding but also for the advancement of cancer therapeutics.
