Analytical Data
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基因名
RALGAPA2
- Application
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别名
250 kDa substrate of Akt; Akt substrate AS250; AS250; bA287B20.1; dJ1049G11; dJ1049G11.4; KIAA1272; p220; Ral GTPase-activating protein alpha subunit 2; Ral GTPase-activating protein subunit alpha-2; RALGAPA2; RapGAPalpha2; RGPA2_HUMAN; RP11-470C13.2
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种属
Human
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表达系统
E. coli
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标签
GST-tag at N-terminal
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q2PPJ7
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表达区间
1-237 aa
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氨基酸序列
MNSWDRRKNFHLLKKNSKLLRELKNLDSRQCRETHKIAVFYIAEGQEDKCSILSNERGSQAYEDFVAGLGWEVDLSTHCGFMGGLQRNGSTGQTAPYYATSTVEVIFHVSTRMPSDSDDSLTKKLRHLGNDEVHIVWSEHSRDYRRGIIPTAFGDVSIIIYPMKNHMFFIAITKKPEVPFFGPLFDGAIVSGKLLPSLVCATCINASRAVKCLIPLYQSFYEERALYLEAKFRTTAK
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分子量
51.81 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
RALGAPA2, a member of the RalGAP family, plays a pivotal role in the regulation of the Ral small GTPases, which are involved in diverse cellular processes such as cell proliferation, differentiation, and survival. Understanding the function of RALGAPA2 is particularly important due to its implications in various diseases, including cancer, where aberrant Ral signaling has been linked to tumorigenesis and metastasis. The study of RALGAPA2 as a recombinant protein allows researchers to investigate its biochemical properties, interaction with Ral proteins, and the mechanistic pathways it regulates within the cell. By utilizing techniques such as protein purification and functional assays, scientists aim to elucidate the specific roles of RALGAPA2 in cellular signaling networks. Moreover, the exploration of RALGAPA2 expression patterns and its regulation in different cellular contexts can provide insights into its potential as a therapeutic target. Recent advances in molecular biology techniques have facilitated the generation of high-quality recombinant RALGAPA2, paving the way for detailed studies that could reveal its contributions to health and disease. As researchers delve deeper into the molecular function of this protein, it could lead to novel strategies for intervention in Ral-driven pathologies, further highlighting the significance of RALGAPA2 in both basic and translational research.
