Analytical Data
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Gene name
RABGGTA
- Application
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Alternative Names
Geranylgeranyl transferase type 2 subunit alpha; Geranylgeranyl transferase type II subunit alpha; Geranylgeranyl transferase type-2 subunit alpha; PGTA_HUMAN; Protein prenyltransferase alpha subunit repeat containing 3; PTAR3; Rab geranyl geranyltransferase subunit alpha; Rab geranyl-geranyltransferase subunit alpha; Rab geranylgeranyltransferase alpha subunit; Rab geranylgeranyltransferase subunit alpha; Rab GG transferase alpha; Rab GGTase alpha; RABGGTA
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q92696
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Expression Region
1-567 aa
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AA Sequence
MHGRLKVKTS EEQAEAKRLE REQKLKLYQS ATQAVFQKRQ AGELDESVLE LTSQILGANP DFATLWNCRR EVLQQLETQK SPEELAALVK AELGFLESCL RVNPKSYGTW HHRCWLLGRL PEPNWTRELE LCARFLEVDE RNFHCWDYRR FVATQAAVPP AEELAFTDSL ITRNFSNYSS WHYRSCLLPQ LHPQPDSGPQ GRLPEDVLLK ELELVQNAFF TDPNDQSAWF YHRWLLGRAD PQDALRCLHV SRDEACLTVS FSRPLLVGSR MEILLLMVDD SPLIVEWRTP DGRNRPSHVW LCDLPAASLN DQLPQHTFRV IWTAGDVQKE CVLLKGRQEG WCRDSTTDEQ LFRCELSVEK STVLQSELES CKELQELEPE NKWCLLTIIL LMRALDPLLY EKETLQYFQT LKAVDPMRAT YLDDLRSKFL LENSVLKMEY AEVRVLHLAH KDLTVLCHLE QLLLVTHLDL SHNRLRTLPP ALAALRCLEV LQASDNAIES LDGVTNLPRL QELLLCNNRL QQPAVLQPLA SCPRLVLLNL QGNPLCQAVG ILEQLAELLP SVSSVLT
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Molecular Weight
65.0 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
RABGGTA, a member of the Rab family of small GTPases, plays a pivotal role in intracellular membrane trafficking and regulation of vesicle transport. Research on RABGGTA has gained attention due to its involvement in various cellular processes, including endocytosis and exocytosis, which are essential for maintaining cellular homeostasis and signaling. Notably, dysregulation of RABGGTA has been linked to several diseases, including neurodegenerative disorders and cancer, making it a critical target for therapeutic interventions. Scientists are increasingly focusing on the recombinant expression of RABGGTA to better understand its structure-function relationships and biochemical mechanisms. By producing recombinant RABGGTA, researchers can study its interactions with other proteins, the effects of post-translational modifications, and its role in disease pathology. The development of efficient expression systems, combined with advanced techniques such as cryo-electron microscopy and protein crystallography, has significantly enhanced our understanding of RABGGTA’s function at the molecular level. Overall, ongoing research into recombinant RABGGTA is expected to provide valuable insights into its biological significance and potential as a drug target, thus highlighting its importance in both fundamental biology and translational medicine.
