Analytical Data
-
基因名
PTPN12
- Application
-
别名
PTPN12；Tyrosine-Protein phosphatase non-receptor type 12
-
种属
Human
-
表达系统
E. coli
-
标签
His tag N-Terminus
-
纯度
Greater than 90% as determined by SDS-PAGE.
-
蛋白编号
Q05209
-
表达区间
1-780aa
-
氨基酸序列
MEQVEILRKFIQRVQAMKSPDHNGEDNFARDFMRLRRLSTKYRTEKIYPT ATGEKEENVKKNRYKDILPFDHSRVKLTLKTPSQDSDYINANFIKGVYGP KAYVATQGPLANTVIDFWRMIWEYNVVIIVMACREFEMGRKKCERYWPLY GEDPITFAPFKISCEDEQARTDYFIRTLLLEFQNESRRLYQFHYVNWPDH DVPSSFDSILDMISLMRKYQEHEDVPICIHCSAGCGRTGAICAIDYTWNL LKAGKIPEEFNVFNLIQEMRTQRHSAVQTKEQYELVHRAIAQLFEKQLQL YEIHGAQKIADGVNEINTENMISSIEPEKQDSPPPKPPRTRSCLVEGDAK EEILQPPEPHPVPPILTPSPPSAFPTVTTVWQDNDRYHPKPVLHMVSSEQ HSADLNRNYSKSTELPGKNESTIEQIDKKLERNLSFEIKKVPLQEGPKSF DGNTLLNRGHAIKIKSASPCIADKISKPQELSSDLNVGDTSQNSCVDCSV TQSNKVSVTPPEESQNSDTPPRPDRLPLDEKGHVTWSFHGPENAIPIPDL SEGNSSDINYQTRKTVSLTPSPTTQVETPDLVDHDNTSPLFRTPLSFTNP LHSDDSDSDERNSDGAVTQNKTNISTASATVSAATSTESISTRKVLPMSI ARHNIAGTTHSGAEKDVDVSEDSPPPLPERTPESFVLASEHNTPVRSEWS ELQSQERSEQKKSEGLITSENEKCDHPAGGIHYEMCIECPPTFSDKREQI SENPTEATDIGFGNRCGKPKGPRDPPSEWT
-
分子量
115 kDa
-
内毒素
< 1.0 EU per μg protein as determined by the LAL method.
-
性状
Freeze-dried powder
-
缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
-
复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
-
稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
-
保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
-
运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
PTPN12, also known as protein tyrosine phosphatase, non-receptor type 12, is an important enzyme involved in various cellular processes, including cell signaling, migration, and adhesion. Its role in dephosphorylating tyrosine residues on target proteins highlights its significance in regulating signaling pathways, particularly those associated with cancer progression and immune responses. Dysregulation of PTPN12 has been implicated in several diseases, including cancer, where it may function as a tumor suppressor or an oncogene depending on the context. This dual role makes it a compelling target for therapeutic interventions. Research into recombinant PTPN12 seeks to better understand its functional mechanisms and biological significance, facilitating the development of novel diagnostic and therapeutic strategies. Producing PTPN12 as a recombinant protein allows for in-depth biochemical analyses, providing insights into its structure-function relationships and interactions with other signaling molecules. Overall, investigating PTPN12 through recombinant technology not only advances our knowledge of its biological roles but also holds potential for identifying new avenues for disease treatment and drug development.
