Analytical Data
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Gene name
R3HDML
- Application
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Alternative Names
CRSPL; CRSPL_HUMAN; Cysteine-rich secretory protein R3HDML; dJ881L22.3; Peptidase inhibitor R3HDML; R3H domain containing like; R3hdml
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q9H3Y0
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Expression Region
57-253 aa
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AA Sequence
HISV RDMNALLDYH NHIRASVYPP AANMEYMVWD KRLARAAEAW ATQCIWAHGP SQLMRYVGQN LSIHSGQYRS VVDLMKSWSE EKWHYLFPAP RDCNPHCPWR CDGPTCSHYT QMVWASSNRL GCAIHTCSSI SVWGNTWHRA AYLVCNYAIK GNWIGESPYK MGKPCSSCPP SYQGSCNSNM CFKGLKSNKF TWF
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Molecular Weight
28.6 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
R3HDML (R3H domain and LEM domain-containing protein) is a newly identified protein implicated in various cellular processes, including gene regulation, chromatin organization, and cellular stress response. Research indicates that R3HDML plays a significant role in modulating the immune response and may influence the development of certain diseases, including cancer and autoimmune disorders. Previous studies have shown that the protein is involved in the nuclear transport of specific substrates, which is crucial for maintaining cellular function. Moreover, the presence of both R3H and LEM domains in R3HDML suggests a potential interaction with RNA and chromatin, hinting at its involvement in RNA metabolism and epigenetic regulation. The exploration of R3HDML's biological functions and mechanisms of action is still in its early stages, calling for further investigation into its role in health and disease. Researchers are particularly interested in creating recombinant versions of R3HDML to study its structure-function relationships, protein interactions, and potential therapeutic applications. Understanding the complexities surrounding R3HDML could provide valuable insights into its functionality and significance in the context of cellular biology, opening new avenues for targeted therapies in relevant pathologies.
