Analytical Data
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Gene name
PTGS2
- Application
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Alternative Names
PTGS2；COX2；Prostaglandin G/H synthase 2
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
P35354
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Expression Region
18-601aa
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AA Sequence
ANPCCSHPCQNRGVCMSVGFDQYKCDCTRTGFYGENCSTPEFLTRIKLFLKPTPNTVHYILTHFKGFWNVVNNIPFLRNAIMSYVLTSRSHLIDSPPTYNADYGYKSWEAFSNLSYYTRALPPVPDDCPTPLGVKGKKQLPDSNEIVEKLLLRRKFIPDPQGSNMMFAFFAQHFTHQFFKTDHKRGPAFTNGLGHGVDLNHIYGETLARQRKLRLFKDGKMKYQIIDGEMYPPTVKDTQAEMIYPPQVPEHLRFAVGQEVFGLVPGLMMYATIWLREHNRVCDVLKQEHPEWGDEQLFQTSRLILIGETIKIVIEDYVQHLSGYHFKLKFDPELLFNKQFQYQNRIAAEFNTLYHWHPLLPDTFQIHDQKYNYQQFIYNNSILLEHGITQFVESFTRQIAGRVAGGRNVPPAVQKVSQASIDQSRQMKYQSFNEYRKRFMLKPYESFEELTGEKEMSAELEALYGDIDAVELYPALLVEKPRPDAIFGETMVEVGAPFSLKGLMGNVICSPAYWKPSTFGGEVGFQIINTASIQSLICNNVKGCPFTSFSVPDPELIKTVTINASSSRSGLDDINPTVLLKERS
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Molecular Weight
70.9kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
PTGS2, also known as cyclooxygenase-2 (COX-2), is an enzyme that plays a crucial role in the inflammatory response and is involved in the biosynthesis of prostaglandins from arachidonic acid. It is typically induced during inflammation and is associated with various pathophysiological processes, including cancer, cardiovascular diseases, and neurodegenerative disorders. The regulation of PTGS2 expression is complex, with various cytokines, growth factors, and cellular stressors influencing its activity. Given its significant role in disease mechanisms, PTGS2 has emerged as a potential therapeutic target. Research into PTGS2 recombinant proteins aids in understanding enzyme functionality, regulation mechanisms, and interactions with pharmaceutical compounds. The production of PTGS2 recombinant proteins using techniques such as recombinant DNA technology enables detailed biochemical studies and the development of specific inhibitors. These inhibitors hold promise for treating diseases characterized by chronic inflammation and aberrant prostaglandin signaling. Furthermore, the study of PTGS2 through recombinant proteins can facilitate the identification of novel biomarkers for disease diagnosis and prognosis, ultimately contributing to personalized medicine approaches. Understanding PTGS2's structure-function relationship is essential for designing effective therapeutic interventions, making it a focal point of biomedical research in the quest to mitigate inflammatory-related pathologies.
