Analytical Data
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Gene name
PTTG2
- Application
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Alternative Names
Pituitary tumor transforming 2; Pituitary tumor transforming gene 2 protein; Pituitary tumor-transforming gene 2 protein; PTTG2; PTTG2_HUMAN; Securin-2
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q9NZH5
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Expression Region
2-202 aa
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AA Sequence
ATLIYVDKE IGEPGTRVAA KDVLKLESRP SIKALDGISQ VLTRRFGKTY DAPSALPKAT RKALGTVNRA TEKSVKTNGP RKQKQPSFSA KKMTEKTVKT KSSVPASDDA YPEIEKFFPF NLLDFESFDL PEERQIAHLP LSGVPLMILD EEGELEKLFQ LGPPSPVKMP SPPWECNLLQ SPSSILSTLD VELPAVCYDI DI
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Molecular Weight
22.3 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
PTTG2 (Pituitary Tumor-Transforming Gene 2) is a member of the PTTG family, which has been implicated in several critical biological processes, including cell cycle regulation, chromosome stability, and tumorigenesis. Its overexpression has been associated with various cancers, highlighting its potential as a biomarker and therapeutic target. The study of PTTG2 recombinant proteins has emerged as a significant focus in cancer research, as understanding its structure and function can provide insights into its role in oncogenesis. Researchers aim to characterize the protein's interactions with other cellular components, elucidating pathways that lead to tumor development. The production of recombinant PTTG2 allows for detailed functional studies, including assessing its impact on cell proliferation and apoptosis in cancer cells. Furthermore, investigating PTTG2’s role in chromosomal segregation can contribute to our knowledge of tumorigenic processes, as chromosomal instability is a hallmark of many malignancies. Overall, the exploration of PTTG2 recombinant protein stands at the intersection of molecular biology and cancer therapeutics, with the potential to pave the way for innovative diagnostic and treatment strategies.
