Analytical Data
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Gene name
PTGFR
- Application
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Alternative Names
PTGFR; Prostaglandin F2-alpha receptor; PGF receptor; PGF2-alpha receptor; Prostanoid FP receptor
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Species
Human
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Source
E. coli
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Tag
GST-tag at N-terminal
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
P43088
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AA Sequence
MSMNNSKQLVSPAAALLSNTTCQTENRLSVFFSVIFMTVGILSNSLAIAILMKAYQRFRQKSKASFLLLASGLVITDFFGHLINGAIAVFVYASDKEWIRFDQSNVLCSIFGICMVFSGLCPLLLGSVMAIERCIGVTKPIFHSTKITSKHVKMMLSGVCLFAVFIALLPILGHRDYKIQASRTWCFYNTEDIKDWEDRFYLLLFSFLGLLALGVSLLCNAITGITLLRVKFKSQQHRQGRSHHLEMVIQLLAIMCVSCICWSPFLVTMANIGINGNHSLETCETTLFALRMATWNQILDPWVYILLRKAVLKNLYKLASQCCGVHVISLHIWELSSIKNSLKVAAISESPVAEKSAST
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Molecular Weight
40.1 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
Prostaglandin F2alpha (PGF2α) is a bioactive lipid that plays a significant role in various physiological and pathophysiological processes, including reproductive functions, inflammation, and vascular regulation. The prostaglandin F receptor (PTGFR) is a G-protein-coupled receptor (GPCR) that mediates the biological effects of PGF2α, making it a crucial target for therapeutic interventions in conditions like asthma, glaucoma, and cancer. Research has focused on elucidating the structure and function of PTGFR to understand its signaling pathways and interactions at a molecular level. Recombinant PTGFR proteins have been developed to facilitate detailed studies of receptor dynamics, ligand binding affinity, and downstream signaling cascades. Understanding PTGFR's mechanisms can provide insights into the development of selective modulators that can be used in clinical settings to treat diseases associated with dysregulated PGF2α signaling. Furthermore, recombinant PTGFR can serve as a valuable tool in drug discovery, enabling the screening of new pharmacological agents that specifically target this receptor. Overall, ongoing research on PTGFR and its recombinant forms holds promise for advancing our understanding of prostaglandin biology and developing novel therapeutic strategies to combat various diseases.
