Analytical Data
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Gene name
PTGER1
- Application
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Alternative Names
PTGER1; Prostaglandin E2 receptor EP1 subtype; PGE receptor EP1 subtype; PGE2 receptor EP1 subtype; Prostanoid EP1 receptor
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Species
Human
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Source
E. coli
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Tag
GST-tag at N-terminal
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
P34995
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Expression Region
1-402 aa
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AA Sequence
MSPCGPLNLSLAGEATTCAAPWVPNTSAVPPSGASPALPIFSMTLGAVSNLLALALLAQAAGRLRRRRSAATFLLFVASLLATDLAGHVIPGALVLRLYTAGRAPAGGACHFLGGCMVFFGLCPLLLGCGMAVERCVGVTRPLLHAARVSVARARLALAAVAAVALAVALLPLARVGRYELQYPGTWCFIGLGPPGGWRQALLAGLFASLGLVALLAALVCNTLSGLALLRARWRRRSRRPPPASGPDSRRRWGAHGPRSASASSASSIASASTFFGGSRSSGSARRARAHDVEMVGQLVGIMVVSCICWSPMLVLVALAVGGWSSTSLQRPLFLAVRLASWNQILDPWVYILLRQAVLRQLLRLLPPRAGAKGGPAGLGLTPSAWEASSLRSSRHSGLSHF
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Molecular Weight
68.2 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
PTGER1, also known as the prostaglandin E receptor 1, plays a crucial role in mediating the effects of prostaglandin E2 (PGE2), a lipid signaling molecule involved in various physiological and pathological processes. Research into PTGER1 has gained momentum due to its involvement in critical functions such as regulation of inflammation, modulation of immune responses, and promotion of pain. Abnormal PTGER1 signaling has been implicated in numerous diseases, including cancer, cardiovascular disorders, and respiratory ailments. The receptor's ability to activate intracellular signaling pathways, particularly through G-proteins, highlights its potential as a therapeutic target. Given its significance, the study of recombinant PTGER1 protein is essential for elucidating its mechanisms of action and exploring its role in health and disease. Researchers aim to produce and characterize recombinant PTGER1 to facilitate drug discovery and therapeutic development. By generating this protein, scientists can investigate its binding affinity with various ligands, map its signaling pathways, and identify potential modulators of its activity. Such studies contribute to a deeper understanding of PTGER1's biological functions and pave the way for novel interventions in diseases associated with dysregulated prostaglandin signaling.
