Analytical Data
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基因名
SMARCA2
- Application
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别名
SMARCA2；BAF190B；BRM；SNF2A；Probable global transcription activator SNF2L2
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
P51531
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表达区间
700-1216aa
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氨基酸序列
SYYTVAHAISERVEKQSALLINGTLKHYQLQGLEWMVSLYNNNLNGILAD EMGLGKTIQTIALITYLMEHKRLNGPYLIIVPLSTLSNWTYEFDKWAPSV VKISYKGTPAMRRSLVPQLRSGKFNVLLTTYEYIIKDKHILAKIRWKYMI VDEGHRMKNHHCKLTQVLNTHYVAPRRILLTGTPLQNKLPELWALLNFLL PTIFKSCSTFEQWFNAPFAMTGERVDLNEEETILIIRRLHKVLRPFLLRR LKKEVESQLPEKVEYVIKCDMSALQKILYRHMQAKGILLTDGSEKDKKGK GGAKTLMNTIMQLRKICNHPYMFQHIEESFAEHLGYSNGVINGAELYRAS GKFELLDRILPKLRATNHRVLLFCQMTSLMTIMEDYFAFRNFLYLRLDGT TKSEDRAALLKKFNEPGSQYFIFLLSTRAGGLGLNLQAADTVVIFDSDWN PHQDLQAQDRAHRIGQQNEVRVLRLCTVNSVEEKILAAAKYKLNVDQKVI QAGMFDQKSSSHERRAF
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分子量
76 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
SMARCA2 (SWI/SNF-related, matrix-associated, actin-dependent regulator of chromatin, subfamily A, member 2) is a vital ATPase in the SWI/SNF chromatin remodeling complex, which plays a crucial role in regulating gene expression and maintaining chromatin structure. Alterations in SMARCA2 function have been implicated in various cancers and developmental disorders, highlighting its importance in cellular processes. The study of SMARCA2 recombinant proteins has gained attention due to their potential to elucidate the molecular mechanisms behind chromatin dynamics and tumorigenesis. Researchers are particularly interested in understanding how mutations or loss of SMARCA2 affects the chromatin landscape and gene regulatory networks. By expressing and purifying SMARCA2 as a recombinant protein, scientists can investigate its biochemical properties, interaction with other chromatin remodelers, and impact on transcriptional regulation. This research not only contributes to our understanding of basic cellular mechanisms but also provides insights into targeted therapeutic strategies for diseases associated with SMARCA2 dysregulation. The study of SMARCA2 can bridge gaps in our knowledge of chromatin biology and pave the way for novel interventions in cancer treatment and regenerative medicine.
